[methoxy(2-(diphenylphosphanyl)phenyl)methyl]ferrocene | 1256781-83-5

• 英文名称: [methoxy(2-(diphenylphosphanyl)phenyl)methyl]ferrocene
• CAS: 1256781-83-5
• 化学式: C₃₀H₂₇FeOP
• 分子量: 490.365
• InChiKey: GGZAGPLDBQSSLG-WLOLSGMKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  二环己基膦 、 [methoxy(2-(diphenylphosphanyl)phenyl)methyl]ferrocene 以 溶剂黄146 为溶剂， 以76%的产率得到(R)-[dicyclohexylphosphanyl(2-(diphenylphosphanyl)phenyl)methyl]ferrocene
  参考文献：
  名称：

  Synthesis of Exclusively Centrostereogenic 1,3-Bidentate Ferrocenyldiphosphane Ligands and Their Use in Enantioselective Hydrogenations

  摘要：

  Five representatives of a novel class of 1,3-bidentate and exclusively centrostereogenic ferrocenyldiphosphane ligands were prepared from ferrocene in a five-step sequence. The ligands were tested in rhodium-mediated asymmetric hydrogenations of two alkenes (methyl acetamidocinnamate and dimethyl itaconate) and delivered high product enantioselectivities of up to 96% cc. The coordination behavior of one ligand in its square-planar palladium dichloride complex was studied by X-ray diffraction, and the R absolute configuration was determined from the X-ray anomalous dispersion effects.

  DOI：

  10.1021/om100830m
• 作为产物：
  描述：

  [methoxy(2-bromophenyl)methyl]ferrocene 、 二苯基氯化膦 在 C₄H₉Li 作用下， 以 正己烷 、 甲苯 为溶剂， 生成 [methoxy(2-(diphenylphosphanyl)phenyl)methyl]ferrocene
  参考文献：
  名称：

  Synthesis of Exclusively Centrostereogenic 1,3-Bidentate Ferrocenyldiphosphane Ligands and Their Use in Enantioselective Hydrogenations

  摘要：

  Five representatives of a novel class of 1,3-bidentate and exclusively centrostereogenic ferrocenyldiphosphane ligands were prepared from ferrocene in a five-step sequence. The ligands were tested in rhodium-mediated asymmetric hydrogenations of two alkenes (methyl acetamidocinnamate and dimethyl itaconate) and delivered high product enantioselectivities of up to 96% cc. The coordination behavior of one ligand in its square-planar palladium dichloride complex was studied by X-ray diffraction, and the R absolute configuration was determined from the X-ray anomalous dispersion effects.

  DOI：

  10.1021/om100830m