(((3-hydroxypropyl)carbonylcyclopentadienyl)cobalt)-η⁴-cyclooctadiene | 195446-42-5

• 英文名称: (((3-hydroxypropyl)carbonylcyclopentadienyl)cobalt)-η⁴-cyclooctadiene
• CAS: 195446-42-5
• 化学式: C₁₇H₂₃CoO₂
• 分子量: 318.362
• InChiKey: PLORDTPXVCIVGY-GHDUESPLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  (((3-hydroxypropyl)carbonylcyclopentadienyl)cobalt)-η⁴-cyclooctadiene 、 二苯基乙炔 以 对二甲苯 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Overcoming a Tight Coil To Give a Random “Co” Polymer Derived from a Mixed Sandwich Cobaltocene

  摘要：

  Reversible addition-fragmentation transfer (RAFT) polymerization of a eta(5)-cydopentadienylcobalt-eta(4-)cyclobutadiene (CpCoCb) containing monomer under a wide variety of experimental conditions (e.g., different solvents, temperatures, RAFT agents, concentrations, and [RAFT agent]/[initiator]) was examined. In all cases the results revealed that although the monomer was being consumed over the course of the reaction, there was no significant increase in the molecular weight of the resulting polymer. It was determined that as the polymer chain grows (DP approximate to 10), a tight coil morphology was adopted, which hinders the approach of an additional, sterically demanding CpCoCb-containing monomer. This resulted in premature termination/chain transfer reactions rather than an increase in the polymer chain length. To address this problem, methyl acrylate (MA) with its lower steric demand was copolymerized with the bulky CpCoCb-containing monomer to act as a spacer. This provided the necessary steric relief and an opportunity for the metallopolymer to grow. This copolymerization resulted in dramatic improvements in the polydispersity and molecular weight of the end material. In subsequent experiments, the random copolymer was used as a macro-RAFT agent to prepare diblock copolymers, with good control over the molecular weight, allowing for an examination of the self-assembly behavior of the block copolymer in the solid state.

  DOI：

  10.1021/ma501323q
• 作为试剂：
  描述：

  2-甲基-3-丁炔-2-醇 在 (((3-hydroxypropyl)carbonylcyclopentadienyl)cobalt)-η⁴-cyclooctadiene 作用下， 以 甲醇 、 水 为溶剂， 以28%的产率得到alpha,alpha,alpha',alpha',alpha'',alpha''-六甲基苯-1,3,5-三甲醇
  参考文献：
  名称：

  钴催化炔烃在水溶液中的环三聚反应

  摘要：

  华盛顿州立大学化学系 P.O. Box 644630, Pullman, Washington 99164-4630NeXstar Pharmaceuticals, 2860 Wilderness PlaceBoulder, Colorado 80301 收到，1998 年 3 月 5 日许多用于组装环状有机分子的最有用的方法涉及过渡金属催化的环加成。由于芳环是许多生物、药物和聚合物分子的核心，因此炔烃环三聚是一种重要的方法。Vollhardt 是第一个意识到钴催化环三聚在有机合成中的潜力的人。

  DOI：

  10.1021/ja9807284

文献信息

• Cyclotrimerization of phenylacetylene catalyzed by a cobalt half-sandwich complex embedded in an engineered variant of transmembrane protein FhuA
  作者：A. Thiel、D. F. Sauer、M. A. S. Mertens、T. Polen、H.-H. Chen、U. Schwaneberg、J. Okuda

  DOI：10.1039/c8ob01369a

  日期：——

  An (η5-cyclopentadienyl)cobalt(I) complex was covalently incorporated into an engineered variant of the transmembrane protein ferric hydroxamate uptake protein component: A, FhuA ΔCVFtev, using a thiol–ene reaction. A CD spectrum shows the structural integrity of the biohybrid catalyst. MALDI-TOF of the segment containing the anchoring site for the cobalt complex Cys545 confirmed successful conjugation

  的（η 5 -环戊二烯基）合钴（我）配合物共价结合到跨膜蛋白的工程变体铁氧肟酸盐摄取的蛋白质组分：甲，的FhuAΔCVF TEV，使用硫醇-烯反应。CD谱显示了生物杂化催化剂的结构完整性。包含钴复合物Cys545锚定位点的片段的MALDI-TOF证实成功缀合。该生物杂化催化剂催化苯乙炔的环三聚反应，以在水性介质中得到区域异构的1,2,4-和1,3,5-三苯苯的混合物。