| 1428740-58-2

• CAS: 1428740-58-2
• 化学式: BF₄*C₄₄H₄₀CoN₄O₄P₂
• 分子量: 896.571
• InChiKey: RZNMPEFKNIMRLU-WUCHBLMUSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  cobalt(II) tetrafluoroborate hexahydrate 、 ethyl (2E)-2-[2-(diphenylphosphino) benzylidene]hydrazinecarboxylate 以 乙醇 为溶剂， 反应 6.0h， 以23.4%的产率得到
  参考文献：
  名称：

  Synthesis, characterisation and biological activity of Co(III) complex with the condensation product of 2-(diphenylphosphino)benzaldehyde and ethyl carbazate

  摘要：

  A cobalt(III) complex with the condensation derivative of 2-(diphenylphosphino) benzaldehyde and ethyl carbazate was synthesized. X-ray crystal structure was determined for both the ligand and the complex. In the cobalt(III) complex two deprotonated ligand molecules coordinate the metal atom in a distorted octahedral geometry by chelation through the PNO donor system formed by the phosphorus, the imine nitrogen and the carbonyl oxygen. The complex showed a moderate antibacterial activity and a strong cytotoxic activity, stronger than cisplatin. Based on cell cycle progression, apoptotic assays, spectroscopic and electrophoretic studies, it was shown that high cytotoxicity and moderate potential of induction of apoptosis are not consequence of interactions with DNA. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.09.043