Ru2(p-cymene)2(μ4-2,5-dichloro-1,4-benzoquinonato)Cl2 | 1052687-67-8

• 英文名称: Ru2(p-cymene)2(μ4-2,5-dichloro-1,4-benzoquinonato)Cl2
• 英文别名: Ru₂(p-cymene)₂(μ₄-2,5-dichloro-1,4-benzoquinonato)Cl₂；Ru₂(p-cymene)₂(μ₄-dClbq)Cl₂；[((p-cymene)RuCl)2(3,6-dichloro-2,5-dihydroxy-1,4-benzoquinonato(2-))]；[Ru2(p-cymene)2(2,5-dichloro-3,6-dioxy-1,4-benzoquinonato)Cl2]；[(p-cymene)2Rh2(μ-chloranilate)Cl2]
• CAS: 1052687-67-8
• 化学式: C₂₆H₂₈Cl₄O₄Ru₂
• 分子量: 748.458
• InChiKey: MGBCEWMSCJHYGB-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  4,4'-联吡啶 、 Ru2(p-cymene)2(μ4-2,5-dichloro-1,4-benzoquinonato)Cl2 、 silver trifluoromethanesulfonate 以 甲醇 为溶剂， 以75%的产率得到[(p-cymene)4Ru4(μ-chloranilate)2(μ-4,4'-dipyridyl)2](triflate)4
  参考文献：
  名称：

  阳离子芳烃钌金属矩形化合物的合成，分子结构和抗癌活性

  摘要：

  阳离子芳烃钌为基础的，其包括矩形结构的四核配合物已经从得到的双核芳烃钌络合物的[Ru 2（芳烃）2（OO ∩ OO）2氯2 ]（芳烃=对-伞花烃，六甲; OO ∩ OO = 2， 5-羟基-1,4- benzoquinonato，2,5-二氯-1,4- benzoquinonato）通过与吡嗪或联吡啶接头（反应ñ ∩ ñ =吡嗪，4,4'-联吡啶，1,2-双（4- AgO 3 SCF 3的存在下，在甲醇中生成-[吡啶基）乙烯），形成通式为[Ru 4]的四核阳离子（芳烃）4（Ñ ∩ Ñ）2（OO ∩ OO）2 ] 4+。所有复合物均以三氟甲磺酸盐的形式高收率分离，并通过NMR和IR光谱进行表征，并通过循环伏安法进行研究。已经使用卵巢A2780癌细胞建立了4,4'-联吡啶和1,2-双（4-吡啶基）乙烯系列水溶性化合物的细胞毒性。合并有1，2-双（4-吡啶基）乙烯连接基的大矩形为约。的5倍以上的细胞毒性（IC

  DOI：

  10.1021/om900359j
• 作为产物：
  描述：

  [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 氯冉酸 以 甲醇 为溶剂， 以74%的产率得到Ru2(p-cymene)2(μ4-2,5-dichloro-1,4-benzoquinonato)Cl2
  参考文献：
  名称：

  六核芳烃钌笼中的芳香分子包封：一种策略，以悬挂臂突出的方式建立有机金属支架复合物棱镜

  摘要：

  2,4,6-三（吡啶-4-基）-1,3,5-三嗪（tpt）亚基与对伞花烯（p- Pr i C 6 H 4 Me）或六甲基苯（C 6）的自组装Me 6）钌构件和2,5-二羟基-1,4-苯并喹啉酮（dhbq）或2,5-二氯-3,6-二羟基-1,4-苯并喹啉酮（dchq）桥可提供三棱柱形有机金属阳离子[ Ru 6（p- Pr i C 6 H 4 Me）6（tpt）2（dhbq）3 ] 6+（[ 1 ] 6+），[Ru6（p- Pr i C 6 H 4 Me）6（tpt）2（dchq）3 ] 6+（[ 2 ] 6+），[Ru 6（C 6 Me 6）6（tpt）2（dhbq）3 ] 6+（[ 3 ] 6+）和[Ru 6（C 6 Me 6）6（tpt）2（dchq）3 ] 6+（[ 4 ] 6+）。这些六核阳离子笼以三氟甲磺酸盐的高收率被分离出来。所述的组件1 - 4也可以在大的芳族分子如芘，荧蒽，苯并[存在实现ë

  DOI：

  10.1021/om800419s

文献信息

• Combining coordination and hydrogen-bonds to form arene ruthenium metalla-assemblies
  作者：Divambal Appavoo、Diego Carnevale、Robert Deschenaux、Bruno Therrien

  DOI：10.1016/j.jorganchem.2016.10.011

  日期：2016.12

  dinuclear arene ruthenium clips, (p-cymene)2Ru2(OO∩OO)Cl2 (OO∩OO = oxalato, 2,5-dioxido-1,4-benzoquinonato, 2,5-dichloro-1,4-benzoquinonato, 5,8-dioxido-1,4-naphtoquinonato), twelve cationic arene ruthenium metalla-cycles of the general formula [(p-cymene)2Ru2(OO∩OO)(N-LH)2]2(CF3SO3)4. The ureido-pyrimidone moieties are able to form strong hydrogen-bonds by self-pairing, thus giving rise to dimeric structures

  使用三种脲基-嘧啶酮衍生物（NL H）与四个双核芳烃钌夹（p- cymene）2 Ru 2（OO∩OO）Cl 2（OO∩OO=草酸，2,5-二氧化物- 1,4-苯并喹啉酮，2,5-二氯-1,4-苯并喹啉酮，5,8-二氧化物-1,4-萘并喹啉酮），十二个通式为[（p- cymene）2 Ru的阳离子芳烃钌金属环2（OO∩OO）（NL H）2 ] 2（CF 3 SO 3）4。脲基-嘧啶酮部分能够通过自配对形成强氢键，从而在溶液中产生二聚结构。另外，为了更好地理解溶液中的四核金属环的行为，还制备并表征了具有通式（p- cymene）RuCl 2（NL H）} 2的中性双核芳烃钌脲基-嘧啶酮配合物。通过NMR光谱研究了溶液中的所有金属组装，证实了金属循环的高稳定性以及氢键在构建超分子组装中的有用性。
• Synthesis, antimicrobial and antiproliferative activities of new self-assembly benzimidazole-bridged aren ruthenium rectangles in human breast cancer cells
  作者：Ersin Orhan、Görkem Dülger、Merve Alpay、Nilüfer Öksüz、Başaran Dülger

  DOI：10.1007/s10847-021-01099-x

  日期：2022.2

  Some novel benzimidazole-bridged aren ruthenium rectangle compounds of the general structure [Ru2(p-cymene)2(µ4-OO∩OO)}2(µ4-bbim)]4+ (bbim = 1,1′-butyl-2-ene-di(benzimidazole) were obtained from the corresponding double-nuclear arene ruthenium compounds [Ru2(p-cymene)2(µ4-OO∩OO)Cl2] (OO∩OO = 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dibromo-1,4-benzoquinonato (dBrbq), oxalato (oxa), and 5,8-dioxido-1,4-naphtoquinonato (donq) via reaction with the bbim molecule and AgCF3SO3. The antiproliferative activity and anti-cancer properties of the tetranuclear arene ruthenium compounds were evaluated against the human breast cancer cell line (MDA-231-MB). Compound 2 showed the highest antiproliferative effect among the compounds during 24- and 48-h administration. In addition, all other compounds exhibited very good cancer cell selectivity and very low micromolar cytotoxicity. The antimicrobial activities of the synthesized compounds were also determined against various test microorganisms. Evaluations were carried out using the disk diffusion method and the dilution method. In particular, the compounds exhibited more potential antibacterial effects against Gram negative bacteria than against Gram positive bacteria and showed a superior antifungal effect against Candida species. The results revealed the benzimidazole-bridged aren ruthenium rectangle compounds to be very strong and potent inhibitors.

  从相应的双核炔钌化合物[Ru2(p-cymene)2(µ4-OO∩OO)}2(µ4-bbim)]4+（bbim = 1、1′-butyl-2-ene-di(benzimidazole) 从相应的双核芴钌化合物 [Ru2(p-cymene)2(µ4-OO∩OO)Cl2] 中得到（OO∩OO = 2、Cl2]（OO∩OO = 2,5-二氧代-1,4-苯醌（dobq）、2,5-二氯-1,4-苯醌（dClbq）、2,5-二溴-1,4-苯醌（dBrbq）、草酸（oxa）和 5,8-二氧代-1,4-萘醌（donq））。研究人员评估了四核芳香族钌化合物对人类乳腺癌细胞系（MDA-231-MB）的抗增殖活性和抗癌特性。在给药 24 和 48 小时期间，化合物 2 的抗增殖效果最高。此外，所有其他化合物都具有很好的癌细胞选择性和很低的微摩尔细胞毒性。还测定了合成化合物对各种测试微生物的抗菌活性。评估采用了盘扩散法和稀释法。特别是，这些化合物对革兰氏阴性菌的潜在抗菌效果优于对革兰氏阳性菌的抗菌效果，对白色念珠菌的抗真菌效果也更出色。研究结果表明，苯并咪唑桥接钌矩形化合物是一种非常强效的抑制剂。
• Coordination-driven self-assembly formation of Ru(II)-metallocycles based on 4-amino-1,8-naphthalimide Tröger's base supramolecular scaffold: Synthesis, characterization, and heparin-binding study
  作者：Binduja Mohan、Ananthu Shanmughan、Mannanthara Kunhumon Noushija、Dipanjana Sarkar、Purti Patel、Sankarasekaran Shanmugaraju

  DOI：10.1016/j.tchem.2024.100071

  日期：2024.3

  The synthesis, photophysics, and heparin poly-anion binding properties of a series of [2 + 2] self-assembled cationic Ru(II) metallocycles () based on green-emitting 4-amino-1,8-naphthalimide Tröger's base () scaffold are described. [Display omitted]

  基于发绿光 4-氨基-1,8-萘二甲酰亚胺 Tröger 碱 () 的一系列 [2 + 2] 自组装阳离子 Ru(II) 金属环 () 的合成、光物理学和肝素聚阴离子结合特性支架进行了描述。 [显示省略]
• Stepwise Formation of Molecular Rectangles of Half-Sandwich Rhodium and Ruthenium Complexes Containing Bridging Chloranilate Ligands
  作者：Ying-Feng Han、Wei-Guo Jia、Yue-Jian Lin、Guo-Xin Jin

  DOI：10.1021/om800490s

  日期：2008.10.13

  Binuclear complexes [Cp*Rh-2(2)(mu-CA)Cl-2] (2a) and [(p-cymene)(2)Ru-2(mu-CA)Cl-2] (2b) (CA = chloranilate) were obtained by the reactions of [Cp*RhCl(mu-Cl)](2) (1a) or [(p-cymene)RuCl(mu-Cl)](2) (1b) with H(2)CA in the presence of base, respectively. Treatment of 2a or 2b with bidentate ligands (L) such as pyrazine, 4,4'-dipyridine (bpy), 2,5-bis(4-pyridyl)-1,3,5-oxadiazole (bpo), and E-1,2-bis(4-pyridyl)ethene (bpe) in the presence of AgOTf (OTf = CF3SO3) in CH3OH gave the corresponding tetranuclear complexes, with the general formulas [Cp*Rh-4(4)(mu-CA)(2)(mu-L)2](OTf)4 (3a-d) and [(p-eymene)(4)Ru-4(u-CA)(2)(mu-L)(2)](OTf)(4) (4a-d), respectively. The molecular structures Of [Cp*Rh-4(4)(mu-CA)(2)(mu-bpy)(2)](OTf)(4) (3b), [(p-cymene)(4)Ru-4(mu-CA)(2)(mu-bPY)(2)](OTf)(4) (4b), and [(p-cymene)(4)Ru-4(mu-CA)(2)(mu-bPe)(2)](OTf)(4) (4d) have been determined by single-crystal X-ray analysis and revealed that the metal centers were connected by pyridyl ligands and bis-bidentate chloranilate (CA) ligands to construct a rectangular cavity with different dimensions and strong pi interactions between independent molecules to form rectangle channels in the solid state.
• Coordination-driven self-assembly of arene ruthenium metalla-rectangles
  作者：Ersin Orhan、Amine Garci、Bruno Therrien

  DOI：10.1016/j.ica.2017.01.033

  日期：2017.5

  Series of tetranuclear arene ruthenium complexes of the general formula [Ru-4(p-cymene)(4)(mu(2)-N boolean AND N)(2) (mu(4)-OO boolean AND OO2][CF3SO3](4) (N boolean AND N = 2,5- dipyridyl-thiophene (dptp), 3,6-dipyridyl-1,2,4,5-tetrazine (dptz), 3,6-dipyridyl-1,4-dihydro-1,2,4,5-tetrazine (dpdt)) were prepared by reacting the dinuclear arene ruthenium complexes Ru-2(p-cymene)(2)(mu(4)-OO boolean AND OO)Cl-2 (OO boolean AND OO = oxalato (oxa), 2,5-dioxido-1,4-benzoquinonato (dobq), 2,5-dichloro-1,4-benzoquinonato (dClbq), 2,5-dioxido-3-undecyl-1,4-benzoquinonato (dubq), 5,8-dioxido-1,4-naphtoquinonato (donq)) with silver trifluoromethanesulfonate, followed by the addition of the corresponding N boolean AND N linkers. All metalla-rectangles were characterized by standard techniques, including infrared, UV-visible, H-1, C-13 NMR spectroscopy and ESI mass spectrometry: Thus confirming the rectangular structure of the complexes, and showing the facility of forming tetranuclear arene ruthenium metalla-rectangles. (C) 2017 Elsevier B. V. All rights reserved.