cis-tetrahydro-4-methyl-2H-thiopyran 1-oxide | 45612-07-5

• 英文名称: cis-tetrahydro-4-methyl-2H-thiopyran 1-oxide
• 英文别名: cis-4-Methyl-thian-1-oxid
• CAS: 45612-07-5
• 化学式: C₆H₁₂OS
• 分子量: 132.227
• InChiKey: JMEPTQIVALKSSB-WRXNHJIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.17
• 重原子数：
  8.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  4-甲基四氢-2H-噻喃 在 叔丁基过氧化氢 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以9%的产率得到4-methylthiane 1,1-dioxide
  参考文献：
  名称：

  Surface-Mediated Reactions. 8. Oxidation of Sulfides and Sulfoxides with tert-Butyl Hydroperoxide and OXONE¹

  摘要：

  Silica gel and alumina have been found to mediate the oxidation of sulfides and sulfoxides with (CH3)(3)COOH and OXONE. With all combinations except (CH3)(3)COOH/alumina, sulfides were oxidized with reasonably good selectivity to sulfoxides. These studies afforded insights into the mechanisms of surface-mediated processes. Adsorption studies, combined with the effect of partial silylation of silica gel, indicate that oxidation of sulfides by (CH3)(3)COOH/silica gel occurs at least predominantly via nucleophilic attack by the sulfide on (CH3)(3)COOH which is activated by being bound to isolated silanol sites on the silica gel surface (Scheme 2), whereas oxidation of sulfoxides involves nucleophilic attack by (CH3)(3)COOH on the sulfoxide, which is activated by being bound to associated silanol sites (Scheme 3). Oxidation of sulfoxides by (CH3)(3)COOH/alumina involves attack of (CH3)(3)COO- on the sulfoxide bound to free Al+ sites on the surface (Scheme 4B). Mediation of oxidation by OXONE involves instead activation by its being dispersed on the surface of the adsorbent, providing contact between KOSO2OOH, the oxidizing component, and the substrate. With silica gel, binding involves the associated silanol sites (Scheme 5). It is proposed that this is a general model for surface mediation of inorganic salts.

  DOI：

  10.1021/ja9940569

文献信息

• [EN] MALT-1 MODULATORS<br/>[FR] MODULATEURS DE MALT-1
  申请人：EXSCIENTIA LTD

  公开号：WO2022106857A1

  公开（公告）日：2022-05-27

  Disclosed are compounds, compositions and methods for treating disease, syndromes, conditions and disorders that are affected by the modulation of MALT-1. Such compounds are represented by Formula (I) and Formula (II), wherein the variables are defined herein.

  本发明涉及通过调节MALT-1影响的治疗疾病、综合症、病况和疾患的化合物、组合物和方法。这些化合物由公式（I）和公式（II）所表示，其中变量在此定义。