K[PtCl2(1-(1H-pyrrol-2-yl)ethanone oxime)] | 1584652-99-2

• 英文名称: K[PtCl2(1-(1H-pyrrol-2-yl)ethanone oxime)]
• CAS: 1584652-99-2
• 化学式: C₆H₇Cl₂N₂OPt*K
• 分子量: 428.219
• InChiKey: UJAAYBDOUKHVSZ-RKAMWMKASA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1-(1H-pyrrol-2-yl)ethanone oxime 、 potassium tetrachloroplatinate(II) 以 水 为溶剂， 反应 2.0h， 以34%的产率得到K[PtCl2(1-(1H-pyrrol-2-yl)ethanone oxime)]
  参考文献：
  名称：

  Novel Pt(II) complexes containing pyrrole oxime; synthesis, characterization and DNA binding studies

  摘要：

  Since the discovery of anticancer activity and subsequent clinical success of cisplatin (cis-[PtCl2(NH3)(2)]), platinum-based compounds have since been widely synthesized and studied as potential chemotherapeutic agents. In this sense, three novel nuclease active Pt(II) complexes with general formula; [Pt(NH3)CI(L)] (1), [Pt(L)(2)] (2), and K[PtCl2(L)] (3) in which L is 1-H-pyrrole-2-carbaldehyde oxime were synthesized. Characterization of complexes was performed by elemental analysis, FT-IR, H-1 NMR and mass spectroscopy measurements. Interaction of complexes (1-3) with calf thymus deoxyribonucleic acid (ct-DNA) was investigated by using electrochemical, spectroelectrochemical methods and cleavage studies. The hyperchromic change in the electronic absorption spectrum of the Pt(II) complexes indicates an electrostatic interaction between the complexes and ct-DNA. Binding constant values between 4.42 x 10(3) and 5.09 x 10(3) M-1 and binding side size values between 2 and 3 base pairs were determined from cyclic voltammetry (CV) and differential pulse voltammetry (DPV) studies. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2014.02.005