benzyl N2-(tert-butoxycarbonyl)-Nw-nitro-L-arginyl-L-prolylglycinate | 68319-71-1

• 英文名称: benzyl N2-(tert-butoxycarbonyl)-Nw-nitro-L-arginyl-L-prolylglycinate
• CAS: 68319-71-1
• 化学式: C₂₅H₃₇N₇O₈
• 分子量: 563.611
• InChiKey: WKBDZWZBWNVTDG-OALUTQOASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.82
• 重原子数：
  40.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  205.09
• 氢给体数：
  5.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  benzyl N2-(tert-butoxycarbonyl)-Nw-nitro-L-arginyl-L-prolylglycinate 在 盐酸 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 生成 Boc-Ala-Pro-Arg(NO2)-Pro-Gly-OBz
  参考文献：
  名称：

  Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate

  摘要：

  For the purpose of cancer antineovascular therapy, a novel angiogenesis-targeted peptide, Ala-Pro-Arg-Pro-Gly, (APRPG) was attached to hydrophobized polyethylene glycol (distearoylphosphatidylethanolamine [DSPE]-PEG). DSPE-PEG and the 5-mer peptide were condensed with DCC-HOBt method. Liposome modified with this DSPE-PEG-APRPG conjugate highly accumulated in tumor of tumor-bearing mice. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.073
• 作为产物：
  描述：

  methyl ester of N(α)-t-butyloxycarbonyl-N(ω)-nitro-L-arginyl-L-proline 在 sodium hydroxide 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 benzyl N2-(tert-butoxycarbonyl)-Nw-nitro-L-arginyl-L-prolylglycinate
  参考文献：
  名称：

  Synthesis of angiogenesis-targeted peptide and hydrophobized polyethylene glycol conjugate

  摘要：

  For the purpose of cancer antineovascular therapy, a novel angiogenesis-targeted peptide, Ala-Pro-Arg-Pro-Gly, (APRPG) was attached to hydrophobized polyethylene glycol (distearoylphosphatidylethanolamine [DSPE]-PEG). DSPE-PEG and the 5-mer peptide were condensed with DCC-HOBt method. Liposome modified with this DSPE-PEG-APRPG conjugate highly accumulated in tumor of tumor-bearing mice. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.11.073