(η⁵-pentamethylcyclopentadienyl)chloro{meso-[4-(pyridin-2-ylmethoxy)phenyl]dipyrromethenato}rhodium(III) | 1426854-93-4

• 英文名称: (η⁵-pentamethylcyclopentadienyl)chloro{meso-[4-(pyridin-2-ylmethoxy)phenyl]dipyrromethenato}rhodium(III)
• 英文别名: [(η⁵-C₅Me₅)RhCl(2-pcdpm)]
• CAS: 1426854-93-4
• 化学式: C₃₁H₃₁ClN₃ORh
• 分子量: 599.965
• InChiKey: LEPQPLQIIMKYAB-QQUOVXPPSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 meso-[4-(pyridin-2-ylmethoxy)phenyl]dipyrromethene 在 三乙胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 4.0h， 以54%的产率得到(η⁵-pentamethylcyclopentadienyl)chloro{meso-[4-(pyridin-2-ylmethoxy)phenyl]dipyrromethenato}rhodium(III)
  参考文献：
  名称：

  DNA Binding and Anti-Cancer Activity of Redox-Active Heteroleptic Piano-Stool Ru(II), Rh(III), and Ir(III) Complexes Containing 4-(2-Methoxypyridyl)phenyldipyrromethene

  摘要：

  The synthesis of four novel heteroleptic dipyrrinato complexes [(eta(6)-arene)RuCl(2-pcdpm)] (eta(6)-arene = C6H6, 1; C10H14, 2) and [(eta(5)-C5Me5)MCl(2-pcdpm)] (M = Rh, 3; Ir, 4) containing a new chelating ligand 4-(2-methoxypyridyl)-phenyldipyrromethene (2-pcdpm) have been described. The complexes 1-4 have been fully characterized by various physicochemical techniques, namely, elemental analyses, spectral (ESI-MS, IR, H-1, C-13 NMR, UV/vis) and electrochemical studies (cyclic voltammetry (CV) and differential pulse voltammetry (DPV)). Structures of 3 and 4 have been determined crystallographically. In vitro antiproliferative and cytotoxic activity of these complexes has been evaluated by trypan blue exclusion assay, cell morphology, apoptosis, acridine orange/ethidium bromide (AO/EtBr) fluorescence staining, and DNA fragmentation assay in Dalton lymphoma (DL) cell lines. Interaction of 1-4 with calf thymus DNA (CT DNA) has also been supported by absorption titration and electrochemical studies. Our results suggest that in vitro antitumor activity of 1-4 lies in the order 2 > 1 > 4 > 3.

  DOI：

  10.1021/ic302196v