[Ru(η6-p-cymene)(2,2,6,6-tetraazaheptane-3,5-dione(-H))(1,3,5-triaza-7-phosphaadamantane)][BPh4] | 1104968-39-9

• 英文名称: [Ru(η6-p-cymene)(2,2,6,6-tetraazaheptane-3,5-dione(-H))(1,3,5-triaza-7-phosphaadamantane)][BPh4]
• 英文别名: [Ru(eta.6-p-cymene)(tBu2acac)(PTA)][BPh4]
• CAS: 1104968-39-9
• 化学式: C₂₄H₂₀B*C₂₇H₄₅N₃O₂PRu
• 分子量: 894.951
• InChiKey: JGRIUDPVNGRWNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  [Ru(η6-p-cymene)(tBu2acac)Cl] 、 四苯硼钠 、 1,3,5-三氮杂-7-磷杂金刚烷 以 二氯甲烷 、 丙酮 为溶剂， 以73%的产率得到[Ru(η6-p-cymene)(2,2,6,6-tetraazaheptane-3,5-dione(-H))(1,3,5-triaza-7-phosphaadamantane)][BPh4]
  参考文献：
  名称：

  Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η ⁶ ‐ p ‐cymene)(R ₂ acac)(PTA)] ⁺ Complexes (PTA = 1,3,5‐triaza‐7‐phosphaadamantane)

  摘要：

  AbstractA series of compounds of general formula [Ru(η6‐p‐cymene)(R2acac)(PTA)][X] (R2acac = Me2acac, tBu2acac, Ph2acac, Me2acac‐Cl; PTA = 1,3,5‐triaza‐7‐phosphaadamantane; X = BPh4, BF4), and the precursor to the Me2acac‐Cl derivative [Ru(η6‐p‐cymene)(Me2acac‐Cl)Cl], have been prepared and characterised spectroscopically. Five of the compounds have also been characterised in the solid state by X‐ray crystallography. The tetrafluoroborate salts are water‐soluble, quite resistant to hydrolysis, and have been evaluated for cytotoxicity against A549 lung carcinoma and A2780 human ovarian cancer cells. The compounds are cytotoxic towards the latter cell line, and relative activities are discussed in terms of hydrolysis (less important) and lipophilicity, which appears to exert the dominating influence. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  DOI：

  10.1002/ejic.200701291