| 1345891-15-7

• CAS: 1345891-15-7
• 化学式: C₁₁H₂₀Cl₂N₂Pt
• 分子量: 446.279
• InChiKey: REICXCPIYXJLRF-UWIDVKDSSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  16.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.27
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  、 silver nitrate 以 水 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Synthesis and biological evaluation of platinum(II) complexes containing (1R,2R)-N1-alkyl-1,2-diaminocyclohexane and D-(+)-camphorate ligands

  摘要：

  Five platinum(II) complexes with N-monoalkyl derivatives of 1R,2R-diaminocyclohexane as ligands and D-(+)-camphorate anion as leaving group have been synthesized and characterized by elemental analysis, IR, H-1 NMR, ESI-MS, and HRMS spectra. All complexes were evaluated for their in vitro cytotoxicity against four human tumor cell lines and most of them showed promising cytotoxic activity, especially compounds 3 and 4 with branched alkyl substituent at one of nitrogen atoms. Preliminary mechanism study by flow cytometry and agarose gel electrophoresis was also carried out in comparison with cisplatin and oxaliplatin. (C) 2012 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2012.10.011
• 作为产物：
  描述：

  potassium tetrachloroplatinate 、 (1R,2R)-N¹-cyclopentylcyclohexane-1,2-diamine dihydrochloride 在 sodium carbonate 作用下， 以 水 为溶剂， 反应 5.0h， 以89%的产率得到
  参考文献：
  名称：

  Synthesis and in vitro antiproliferative activity of platinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane as ligands

  摘要：

  Nine dichloridoplatinum(II) complexes with N-monoalkyl 1R,2R-diaminocyclohexane as ligands were synthesized and spectrally characterized. Among them, the crystal structure of a typical complex has been determined by X-Ray diffraction. All compounds were evaluated for their in vitro antitumor activity against four human cancer cell lines, which showed selective cytotoxicity comparable to that of positive agents against A549 (human non-small cell lung cancer) cell line. Especially complex 3, cis-[(1R,2R)-N-1-2-butyl-1,2-diaminocyclohexane-N,N'] dichloroplatinum(II), was much more active in vitro (IC50 = 1.82 mu M) than cisplatin against A549. The structure-activity relationship was summarized according to the cytotoxicity and QSAR properties. In addition, flow cytometry and agarose gel electrophoresis experiments were also applied to investigate the mode of action of the representative complexes. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.07.026