[{AuSPh}₂(μ-1,1′-bis-diphenylphosphinoferrocene)] | 185335-07-3

• 英文名称: [{AuSPh}₂(μ-1,1′-bis-diphenylphosphinoferrocene)]
• 英文别名: [{AuSPh}₂(μ-DPPF)]；1,1'-bis[(thiophenylgold(I)diphenyl)phosphino]ferrocene；(AuSPh)2(μ-1,1'-bis(diphenylphosphino)ferrocene)
• CAS: 185335-07-3
• 化学式: C₄₆H₃₈Au₂FeP₂S₂
• 分子量: 1166.67
• InChiKey: GUAHWUJIZWBKIF-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
  None
• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  (1,1'-双(二苯基膦)二茂铁)二氯化二金 、 苯硫酚 在 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 2.17h， 以57%的产率得到[{AuSPh}₂(μ-1,1′-bis-diphenylphosphinoferrocene)]
  参考文献：
  名称：

  金诺芬和相关的异金属金（I）-硫醇盐作为耐甲氧西林金黄色葡萄球菌菌株的有效抑制剂

  摘要：

  合成了一系列含有二茂铁基膦的新型异金属金（I）硫醇盐。研究了它们的抗菌特性，并将其与 FDA 批准的用于治疗类风湿性关节炎的药物金诺芬 (Ridaura) 的抗菌特性进行了比较。大多数针对革兰氏阳性菌金黄色葡萄球菌和 CA MRSA 菌株 US300 和 US400的化合物的 MIC 为一位数微摩尔。值得注意的是，金诺芬以 150–300 nM 的量级抑制金黄色葡萄球菌、US300 和 US400。这是首次描述了金诺芬对 MRSA 菌株的有效抑制作用。还在非致瘤性人胚胎肾细胞系 (HEK-293) 中研究了选定的异金属化合物和金诺芬的作用。

  DOI：

  10.1016/j.jinorgbio.2014.05.008

文献信息

• New potentially cytotoxic thiolatogold(I) complexes of 1,1′-bis(diphenylphosphino)ferrocene
  作者：M. Viotte、B. Gautheron、I. Nifant'ev、L.G. Kuz'mina

  DOI：10.1016/s0020-1693(96)05111-0

  日期：1996.12

  1,1'-Bis[chlorogold(I) diphenylphosphino] ferrocene (1) was chosen as the starting material to synthesize new thiolato gold(I) complexes. This has been achieved by substituting the chlorine atoms by monofunctional and bifunctional thiolates affording 'open' thiolatogold complexes and trimetallic ferrocenophane-type structures, respectively. The new 1,1'-bis(2,6-dithia-1-phosphanyl)ferrocene (7) containing directly linked P and S atoms was also prepared but no gold complex was obtained. Compound 2 crystallizes in the monoclinic space group P2(1)/n with a=10.263(2), b=21.064(4), c=16.259(3) Angstrom, beta=97.06(2)degrees and V=3.488(1) Angstrom(3). The distance between the two gold atoms (3.06 A) indicates a significant contact interaction. Compounds 2-5 have allowed antitumoral efficiency on human bladder and colon carcinoma.
• Synthesis, X-ray molecular structure analysis, and study on ligand scrambling reactions of new thiolatogold(I) complexes with various phosphines
  作者：Satoru Onaka、Yoshitaka Katsukawa、Michito Shiotsuka、Osamu Kanegawa、Masahiro Yamashita

  DOI：10.1016/s0020-1693(00)00353-4

  日期：2001.1

  Treatment of Au(PPh3)Cl, (AuCl)(2)(trans-dpen) and (AuCl)(2)(dppfe) with Sn(SPh)(n-Bu)(3) and/or PhSH/KOH affords Au(PPh3)(SPh) (1), (AuSPh)(2)(mu -trans-dpen) (2), (AuSPh)2(mu -dppfe) (3), (AuSPh)(mu -trans-dpen)(AuCl) (4), and (AuSPh)-(mu -dppfe)(AuCl) (5) in good yields. All these thiophenolates are characterized by single crystal X-ray analysis, H-1 and P-31 NMR spectroscopy. 1 forms tetramer through Au . . . Au interaction and pi-pi interaction between the phenyl group in SPh and one of the phenyl groups in PPh3 in the solid state. An infinite chain structure is formed for 2 through intermolecular aurophilicity and these chains are connected by partial overlap (pi-pi interaction) of neighboring phenyl groups in SPh to give two-dimensional networks in the solid state. Similar infinite chains are formed through aurophilicity, but two-dimensional networks are not formed for 4 in the solid state. No multidimensional structure is formed for 3 and 5 in the solid state. H-1 and P-31 NMR spectroscopy of CDCl3 solutions of 2, 3, 4, and 5 has revealed that rapid ligand scrambling takes place for 4 and 5. (C) 2001 Elsevier Science B.V. All rights reserved.