(2-chloropyridin-4-yl)-[1'-[(E)-3-(3,5-difluorophenyl)prop-2-enyl]-5-(trifluoromethyl)spiro[2H-indole-3,4'-piperidine]-1-yl]methanone | 1322048-86-1

• 英文名称: (2-chloropyridin-4-yl)-[1'-[(E)-3-(3,5-difluorophenyl)prop-2-enyl]-5-(trifluoromethyl)spiro[2H-indole-3,4'-piperidine]-1-yl]methanone
• CAS: 1322048-86-1
• 化学式: C₂₈H₂₃ClF₅N₃O
• 分子量: 547.955
• InChiKey: VPZDJXHSIXUTCH-OWOJBTEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  38
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  36.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] S PIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHI CS<br/>[FR] COMPOSÉS SPIROINDOLINES DESTINÉS À ÊTRE UTILISÉS COMME AGENTS ANTHELMINTHIQUES
  申请人：INTERVET INT BV

  公开号：WO2011095581A1

  公开（公告）日：2011-08-11

  This invention relates to spiroindoline compounds for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  这项发明涉及用于治疗蠕虫感染和寄生虫病的螺环吲哚类化合物。这项发明还涉及利用这些化合物制备药物和治疗方法，包括将这些化合物用于需要治疗的动物的治疗。此外，这项发明还涉及包含这些化合物的药物组合物和工具包。
• SPIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHICS
  申请人：Lutz Jürgen

  公开号：US20120295931A1

  公开（公告）日：2012-11-22

  This invention relates to spiroindoline compounds for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.

  本发明涉及螺环吲哚类化合物，用于治疗蠕虫感染和寄生虫病，如由蠕虫感染引起的病症。本发明还涉及使用这些化合物制备药物和治疗方案，包括将这些化合物用于需要治疗的动物的治疗。此外，本发明还涉及包含这些化合物的药物组合物和工具箱。
• Spiroindoline compounds for use as anthelminthics
  申请人：Intervet International B.V.

  公开号：EP2531506B1

  公开（公告）日：2014-05-14