5-chloro-1-[2-(4-ferrocenyl-[1,2,3]triazol-1-yl)hexyl]-1H-indole-2,3-dione | 1478981-36-0

• 英文名称: 5-chloro-1-[2-(4-ferrocenyl-[1,2,3]triazol-1-yl)hexyl]-1H-indole-2,3-dione
• CAS: 1478981-36-0
• 化学式: C₂₆H₂₅ClFeN₄O₂
• 分子量: 516.81
• InChiKey: WFYHWLROILYQPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  二茂铁乙炔 、 1-(4-azidohexyl)-5-chloro-1H-indole-2,3-dione 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 乙醇 、 水 为溶剂， 以76%的产率得到5-chloro-1-[2-(4-ferrocenyl-[1,2,3]triazol-1-yl)hexyl]-1H-indole-2,3-dione
  参考文献：
  名称：

  Base-Promoted Expedient Access to Spiroisatins: Synthesis and Antitubercular Evaluation of 1H-1,2,3-Triazole-Tethered Spiroisatin–Ferrocene and Isatin–Ferrocene Conjugates

  摘要：

  The use of sodium hydride provides a convenient access to the synthesis of C-5-functionalized spiroisatins with the absence of the typical drawbacks associated with conventional protocols. The synthesized precursors, viz. N-alkylazido spiroisatins and their unprotected counterparts, were explored in Cu-mediated azide alkyne cycloaddition reactions to probe the antitubercular structure-activity relationships (SAR) within the isatin ferrocene-triazole conjugate family. The antitubercular evaluation studies of the synthesized conjugates revealed an improvement in the minimal inhibitory concentration (MIC) with the introduction of ferrocene nucleus, as evidenced by spiroisatin ferrocene and isatin ferrocene hybrids.

  DOI：

  10.1021/om4009229