(di-n-butyltin(iminodiacetate)(H2O))2*1,10-phenanthroline | 1198026-01-5

• 英文名称: (di-n-butyltin(iminodiacetate)(H2O))2*1,10-phenanthroline
• CAS: 1198026-01-5
• 化学式: C₁₂H₈N₂*C₂₄H₅₀N₂O₁₀Sn₂
• 分子量: 944.297
• InChiKey: VFZGOGSBQQJLCF-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 水 、 二乙酸二丁基锡 、 亚氨基二乙酸 以 乙醇 、 水 为溶剂， 以64%的产率得到(di-n-butyltin(iminodiacetate)(H2O))2*1,10-phenanthroline
  参考文献：
  名称：

  Synthesis, crystal structure and in vitro antitumor activity of carboxylate bridged dinuclear organotin(IV) complexes

  摘要：

  Two novel dinuclear organotin(IV) complexes [n-Bu2Sn(imda)(H2O)](2)center dot Bipy (1) and [n-Bu2Sn(imda) (H2O)](2)center dot Phen (2) [H(2)imda = iminodiacetic acid, Bipy = 2,2'-bipyridine and Phen = 1,10-phenanthroline] were synthesised and characterized employing IR, H-1, C-13, Sn-119 NMR, and Sn-119 Mossbauer spectroscopic and elemental analyses. Single crystal X-ray crystallography of 1 has confirmed that it is a binuclear Sn(IV) species formed via carboxylate bridges where each metal adopted a seven coordinate distorted pentagonal bipyramidal geometry. The iminodiacetate dianion (imda(2-)) acts as a potential tridentate [N,O,O] carboxylate bridging ligand. The packing revealed that the additional alpha-diimine (Bipy or Phen) does not coordinate to metal ion. However, its presence in the crystal lattice as spacer helps for the formation of a supramolecular framework by bringing the two binuclear species close enough through extensive H-bonding. The in vitro cytotoxicity of compounds 1 and 2 indicate better results than cisplatin against three tumor cell lines investigated. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2009.07.030