(di(tert-butyl) N-(3-([2-(amino-κN)ethyl]amino-κN)butyl)-N,N'-(ethane-1,2-diyl)bis[carbamate])dichloroplatinum(II) | 392661-38-0

• 英文名称: (di(tert-butyl) N-(3-([2-(amino-κN)ethyl]amino-κN)butyl)-N,N'-(ethane-1,2-diyl)bis[carbamate])dichloroplatinum(II)
• CAS: 392661-38-0
• 化学式: C₁₈H₃₈Cl₂N₄O₄Pt
• 分子量: 640.51
• InChiKey: HQTSLGKKJDRWJN-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  盐酸 、 (di(tert-butyl) N-(3-([2-(amino-κN)ethyl]amino-κN)butyl)-N,N'-(ethane-1,2-diyl)bis[carbamate])dichloroplatinum(II) 以 甲醇 、 水 为溶剂， 以79%的产率得到(N-[2-(amino-κN)ethyl]-N'-(2-aminoethyl)butane-1,4-diamine-κN)dichloroplatinum(II) dihydrochloride
  参考文献：
  名称：

  Mononuclear Tetraamineplatinum(II) Complexes: Synthesis, Anticancer Activity, DNA Binding, and Cellular Uptake

  摘要：

  The synthesis of three bis[(tert-butoxy)carbonyl]-protected (tetramine)dichloroplatinum complexes 2a-c of formula cis-[PtCl2(LL)] and of their cationic deprotected analogs 3a-c and their evaluation with respect to in vitro cytotoxicity, intramolecular stability, DNA binding, and cellular uptake is reported. The synthesis comprises the complexation of K-2[PtCl4] With di-N-protected tetramines la-c to give 2a-c and subsequent acidolysis, yielding 3a-c. The cytotoxicity of the complexes is in direct relation to the length of the polyamine. Complexes 3a-e display a significant higher affinity for CT DNA as well as for cellular DNA in A2780 cells than cisplatin.

  DOI：

  10.1002/1522-2675(20011017)84:10<3023::aid-hlca3023>3.0.co;2-z
• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 Di(tert-butyl)-N-<4-<(2-aminoethyl)amino>butyl>-N,N'-(ethan-1,2-diyl)bis 以 甲醇 、 水 为溶剂， 以87%的产率得到(di(tert-butyl) N-(3-([2-(amino-κN)ethyl]amino-κN)butyl)-N,N'-(ethane-1,2-diyl)bis[carbamate])dichloroplatinum(II)
  参考文献：
  名称：

  Mononuclear Tetraamineplatinum(II) Complexes: Synthesis, Anticancer Activity, DNA Binding, and Cellular Uptake

  摘要：

  The synthesis of three bis[(tert-butoxy)carbonyl]-protected (tetramine)dichloroplatinum complexes 2a-c of formula cis-[PtCl2(LL)] and of their cationic deprotected analogs 3a-c and their evaluation with respect to in vitro cytotoxicity, intramolecular stability, DNA binding, and cellular uptake is reported. The synthesis comprises the complexation of K-2[PtCl4] With di-N-protected tetramines la-c to give 2a-c and subsequent acidolysis, yielding 3a-c. The cytotoxicity of the complexes is in direct relation to the length of the polyamine. Complexes 3a-e display a significant higher affinity for CT DNA as well as for cellular DNA in A2780 cells than cisplatin.

  DOI：

  10.1002/1522-2675(20011017)84:10<3023::aid-hlca3023>3.0.co;2-z