[Pd(PPh3)2(Br)(2-pyridyl-3,4,5,6-tetrafluorophenyl)] | 1422263-73-7

• 英文名称: [Pd(PPh3)2(Br)(2-pyridyl-3,4,5,6-tetrafluorophenyl)]
• CAS: 1422263-73-7
• 化学式: C₄₇H₃₅BrF₄NP₂Pd
• 分子量: 938.067
• InChiKey: WPIJZEBJPOEDMY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Pd(PPh3)2(Br)(2-pyridyl-3,4,5,6-tetrafluorophenyl)] 、 1,2-bis(di-(4-tert-butylphenyl)phosphino)benzene 以 二氯甲烷 为溶剂， 反应 2.0h， 以83%的产率得到[Pd(tBu-DPPBz)(Br)(2-pyridyl-3,4,5,6-tetrafluorophenyl)]
  参考文献：
  名称：

  Palladium-Catalyzed Coupling of Polyfluorinated Arenes with Heteroarenes via C–F/C–H Activation

  摘要：

  The first palladium-catalyzed coupling of 2-pyrldyl-polyfluoroarenes and benzoxazole, thiazole, benzothiazole, benzoimidazole, oxazole or oxadiazole via a concurrent C-F/C-H activation is described. Initial mechanistic studies showed that C-F activation of perfluoroarene is likely the rate-limiting step of the catalytic cycle. This protocol provides a useful and operationally simple process to functionalized polyfluoroarenes.

  DOI：

  10.1021/ol303567t
• 作为产物：
  描述：

  2-溴吡啶 、 四(三苯基膦)钯 、 2,3,4,5-四氟苯硼酸 以 四氢呋喃 为溶剂， 反应 3.0h， 以90%的产率得到[Pd(PPh3)2(Br)(2-pyridyl-3,4,5,6-tetrafluorophenyl)]
  参考文献：
  名称：

  Palladium-Catalyzed Coupling of Polyfluorinated Arenes with Heteroarenes via C–F/C–H Activation

  摘要：

  The first palladium-catalyzed coupling of 2-pyrldyl-polyfluoroarenes and benzoxazole, thiazole, benzothiazole, benzoimidazole, oxazole or oxadiazole via a concurrent C-F/C-H activation is described. Initial mechanistic studies showed that C-F activation of perfluoroarene is likely the rate-limiting step of the catalytic cycle. This protocol provides a useful and operationally simple process to functionalized polyfluoroarenes.

  DOI：

  10.1021/ol303567t