| 1147103-87-4

• CAS: 1147103-87-4
• 化学式: C₁₄H₁₄NO₈PW
• 分子量: 539.091
• InChiKey: BASPWVXINRQHGU-OYNMXQSYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  (η⁵-C₅H₅)W(CO)₃(η¹-N-maleimidato) 、 亚磷酸二甲酯 在 1,8-diazabicyclo[5.4.0]undec-7-ene 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到
  参考文献：
  名称：

  The phospha-Michael addition of dimethyl- and diphenylphosphites to the η1-N-maleimidato ligand: Inhibition of serine hydrolases by half-sandwich metallocarbonyl azaphosphonates

  摘要：

  Dialkyl- and diphenyl phosphites react with the (eta(5)-C5H5)(x)(CO)(x)(eta(1)-N-maleimidato) (M = Fe, Mo; x = 2 or 3) complexes giving products of the phospha-Michael addition to the eta(1)-N-maleimidato ligand. One of these complexes (M=Fe, x=2) was characterized by X-ray diffraction. The synthesized metallocarbonyl azaphosphonates and the corresponding iron phosphonic acid act as inhibitors of certain serine hydrolases (AChE and BChE). The kinetic assays were performed and revealed that inhibition mechanism depends strongly on the enzyme and the structure of the inhibitor. (C) 2008 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.10.057