2'-O-{[3-propyl-(1,12-dicarba-closo-dodecaboran-1-yl)]-1-N-1,2,3-triazol-4-yl}propyladenosine | 1410797-17-9

• 英文名称: 2'-O-{[3-propyl-(1,12-dicarba-closo-dodecaboran-1-yl)]-1-N-1,2,3-triazol-4-yl}propyladenosine
• CAS: 1410797-17-9
• 化学式: C₂₀H₃₆B₁₀N₈O₄
• 分子量: 560.667
• InChiKey: SJOAAOMVWIHHQA-SCFUHWHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2'-O-(1-pentyn-5-yl)adenosine 、 1-(3-azidopropyl)-1,12-dicarba-closo-dodecaborane 在 copper(ll) sulfate pentahydrate 、 potassium ascorbate 作用下， 以 水 、 叔丁醇 为溶剂， 反应 24.0h， 以60%的产率得到2'-O-{[3-propyl-(1,12-dicarba-closo-dodecaboran-1-yl)]-1-N-1,2,3-triazol-4-yl}propyladenosine
  参考文献：
  名称：

  Effect of adenosine modified with a boron cluster pharmacophore on reactive oxygen species production by human neutrophils

  摘要：

  Methods for the synthesis of adenosine/boron cluster conjugates are proposed and the potential of the obtained derivatives to modulate neutrophil activity, especially reactive oxygen species (ROS) production in vitro, is described. An efficient inhibition of ROS production in activated neutrophils by adenosine modified at the 2'-C and 6-N positions with a para-carborane cluster (C2B10H11) was discovered. The high affinity of the selected compounds for adenosine receptor A(2A) was established. These results are in agreement with the possible involvement of receptor A(2A) in the biological activities of adenosine/boron cluster conjugates. This study extends the range of innovative molecules available for testing as agents affecting inflammatory processes. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2012.09.039