cis,trans,cis-[PtCl2(OCOCH3)2(chpda)] | 634585-58-3

• 英文名称: cis,trans,cis-[PtCl2(OCOCH3)2(chpda)]
• 英文别名: cis,trans,cis-[PtCl2(acetato)2(N-cyclohexyl-1,3-propanediamine)]
• CAS: 634585-58-3
• 化学式: C₁₃H₂₆Cl₂N₂O₄Pt
• 分子量: 540.346
• InChiKey: YIXKMQSDHMVOOK-UHFFFAOYSA-J

反应信息

• 作为产物：
  描述：

  cis,trans,cis-[PtCl2(OH)2(N-cyclohexyl-1,3-propanediamine)]*2H2O 、 乙酸酐 以 水 为溶剂， 以62%的产率得到cis,trans,cis-[PtCl2(OCOCH3)2(chpda)]
  参考文献：
  名称：

  Chelate vs monodentate amine effects. Direct comparison of bis(acetato)amminedichloro(cyclohexylamine)platinum(IV) (JM216) with its N-cyclohexyl-1,3-propanediamine analogue

  摘要：

  In order to investigate the chelate effects on physicochemical properties including antitumor activity, new cis,trans,cis,-[(PtCl2L2)-Cl-IV(chpda)] complexes (L = OH, OCOCH3; chpda = N-cyclohexyl-1,3-propanediamine) have been synthesized and characterized. The crystal structure of cis,trans,cis-[(PtCl2)-Cl-IV(OCOCH3)(2)(chpda)] (monoclinic P2(1)/a, a = 7.947(1), b = 22.753(11), and c = 10.581(3) Angstrom, beta = 110.70(2)degrees, V = 1790(1) Angstrom(3), Z = 4, R = 0.0534) shows that the platinum(IV) center adopts a typical octahedral arrangement with two acetate groups in a trans position. The pattern and strength of the intramolecular hydrogen bonds are delicately different from those of JM216. Both in vitro and in vivo (oral) cytotoxicities on mouse leukemia L1210 cell line indicate that the activity of chpda chelate analogue is not better than that of the corresponding compound with two monodentate amines (JM216). (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2003.08.006