Dimethyl-[α-(ethoxy)-ethyliden]-ammonium-Ion | 41948-89-4

• 英文名称: Dimethyl-[α-(ethoxy)-ethyliden]-ammonium-Ion
• 英文别名: Dimethyl-<α-(ethoxy)-ethyliden>-ammonium-Ion；Methyl-dimethylamino-ethoxy-carbonium-hydroxid
• CAS: 41948-89-4
• 化学式: BF₄*C₆H₁₄NO
• 分子量: 202.988
• InChiKey: GOVICZOEEDQZRV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  Dimethyl-[α-(ethoxy)-ethyliden]-ammonium-Ion 生成 N-(1-ethoxyvinyl)-N,N-dimethylamine
  参考文献：
  名称：

  Meerwein,H. et al., Justus Liebigs Annalen der Chemie, 1961, vol. 641, p. 1 - 39

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N-二甲基乙酰胺 、 diphenylethylsulphonium tetrafluoroborate 反应 14.0h， 以70%的产率得到Dimethyl-[α-(ethoxy)-ethyliden]-ammonium-Ion
  参考文献：
  名称：

  O-alkylation d'amides A l'aide de sels d'alkyldiphenylsulfonium

  摘要：

  DOI：

  10.1016/s0040-4020(01)88543-4

文献信息

• Cardiac-slowing amidines containing the 3-thioindole group. Potential antianginal agents
  作者：Michael J. Zelesko、David F. McComsey、William E. Hageman、Samuel O. Nortey、Carol A. Baker、Bruce E. Maryanoff

  DOI：10.1021/jm00356a021

  日期：1983.2

  A series of 3-thioindolamidines (and 3-indolamidines) related to mixidine (1) was studied for cardiac-slowing properties, following the discovery of activity for prototype thioindole 2. Structure-activity relationships were explored, leading to many potent antitachycardiac agents (6-9, 12, 13, 15-17, 20, 23, 24, 30, 34, 35, 45, and 47-49). Relative to 2, cardiac-slowing activity is enhanced by substitution of the indole nitrogen with small (C1-C3) saturated alkyl groups (6-9), unsaturated alkyl groups (12, 13, and 15-17), or a methoxyethyl group (20); replacement of the N-methyl group with alkyl (23) or phenyl groups (24); and extension of the ethylene bridge by two methylene units (34). Dethio (i.e., 3-indole) analogues of 2 with alkyl substitution on the indole nitrogen (47-49) have greater activity as well. Several potent compounds were also found to have minimal myocardial depression (6-9, 13, 45, and 47). Secondary pharmacological testing is reported for thioindoles 2, 6, 7, 9, and 28.
• Hydrolysis of N,N-disubstituted imidate esters
  作者：Vincent F. Smith、Gaston L. Schmir

  DOI：10.1021/ja00844a041

  日期：1975.5
• Aumann, Rudolf; Hinterding, Peter, Chemische Berichte, 1990, vol. 123, p. 611 - 620
  作者：Aumann, Rudolf、Hinterding, Peter

  DOI：——

  日期：——
• Plieninger,H. et al., Chemische Berichte, 1971, vol. 104, p. 3983 - 3985
  作者：Plieninger,H. et al.

  DOI：——

  日期：——
• Issleib, Kurt; Leissring, Elke; Riemer, Manfred, Zeitschrift fur Chemie, 1983, vol. 23, # 3, p. 99 - 100
  作者：Issleib, Kurt、Leissring, Elke、Riemer, Manfred、Oehme, Hartmut

  DOI：——

  日期：——