[RuCl2(DMSO)2(thiophene-2-carboxylic acid hydrazide)]*H2O | 1173819-99-2

• 英文名称: [RuCl2(DMSO)2(thiophene-2-carboxylic acid hydrazide)]*H2O
• CAS: 1173819-99-2
• 化学式: C₉H₁₈Cl₂N₂O₃RuS₃*H₂O
• 分子量: 488.443
• InChiKey: KJTKFZPZIBUWAT-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  水 、 2-噻吩甲酰肼 、 dichlorotetrakis(dimethylsulfoxide)ruthenium 以 乙醇 为溶剂， 以66%的产率得到[RuCl2(DMSO)2(thiophene-2-carboxylic acid hydrazide)]*H2O
  参考文献：
  名称：

  Ru(II)–DMSO complexes containing aromatic and heterocyclic acid hydrazides: Structure, electrochemistry and biological activity

  摘要：

  The reaction of cis-[RuCl2(DMSO)(4)] with a family of aromatic and heterocyclic acid hydrazides yielded new complexes of the general formula trans-[RuCl2(DMSO)(2)(hydrazide)] center dot nH(2)O (n = 0; 1-6; n = 1; 7). The new complexes have been characterized by IR, UV-Vis and H-1 NMR spectroscopic methods. In addition, the structure of one of the complexes, [RuCl2(DMSO)(2)(tcah)] center dot H2O (tcah = thiophene-2-carboxylic acid hydrazide), has been determined by single crystal X-ray diffraction. All the studies reveal the neutral bidentate coordination of the hydrazide ligands through the acyl oxygen and amine nitrogen atoms. The electron transfer properties of the complexes were studied by cyclic voltammetry and all the complexes except one show an irreversible/quasi-reversible reduction wave (Ru-II/Ru-I) and an uncoupled oxidation peak (Ru-III/Ru-II). The preliminary DNA-binding ability of the complexes, studied with herring sperm DNA, shows the binding of the complexes with DNA with a lesser affinity than classical intercalators. The complexes have also been screened for their antibacterial activity against five pathogenic bacteria. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2009.03.023