[(η6-cymene)Ru(2,2'-biquinoline)Cl](PF6) | 671191-36-9

• 英文名称: [(η6-cymene)Ru(2,2'-biquinoline)Cl](PF6)
• CAS: 671191-36-9
• 化学式: C₂₈H₂₆ClN₂Ru*F₆P
• 分子量: 672.015
• InChiKey: KGGOWHRTZYZQKT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  ammonium hexafluorophosphate 、 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 2,2'-联喹啉 以 甲醇 、 二氯甲烷 为溶剂， 以70.76%的产率得到[(η6-cymene)Ru(2,2'-biquinoline)Cl](PF6)
  参考文献：
  名称：

  Reactivity studies of η6-arene ruthenium (II) dimers with polypyridyl ligands: isolation of mono, binuclear p-cymene ruthenium (II) complexes and bisterpyridine ruthenium (II) complexes

  摘要：

  The complexes [(eta(6)-p-cymene)RuCl(L-2)](+) where L-2 = 2,2'-biquinoline (biqui) (3), 2,9-dimethyl 4,7-diphenyl-1,10-phenanthroline (ddp) (4), and 2,3-bis(alpha-pyridyl) quinoxaline (bpq) (5) were obtained by halide bridge cleavage of [{(eta(6)-p-cymene)Ru(mu-Cl)}(2)Cl-2] (1) with the corresponding ligands. The ligand bridged binuclear compound [{(eta(6)-cymene)RuCl}(2)(bpq)](2+) (6) was also obtained by treating I with stoichiometric amount of bpq in methanol. The reactions of [{(eta(6)-arene)Ru(mu-Cl)}(2)Cl-2], {arene=p-cymene (1), hexamethylbenzene (2)1 with substituted phenylterpyridines (x-phterpy, x = H, CH3, OCH3) yielded his terpyridine complexes of the type [(x-phterpy)(2)Ru](2+) by the facile displacement of eta(6)-arene ring as well as chloride ligands. These complexes were characterized by FT-NMR, FT-IR spectroscopy, and analytical data. The molecular structures of [(eta(6)-p-cymene)RuCl(biqui)]PF6 (3) and [(eta(6)-p-cymene)RuCl(bpq)]PF6 (5) have been determined by single crystal X-ray diffraction study. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0277-5387(03)00460-1

文献信息

• Synthesis, characterization, photophysical and electrochemical properties, and biomolecular interaction of 2,2′-biquinoline based phototoxic Ru(<scp>ii</scp>)/Ir(<scp>ii</scp>) complexes
  作者：Utpal Das、Priyankar Paira

  DOI：10.1039/d3dt01348k

  日期：——

  design of phototoxic molecules has been of growing interest in research to establish a selective strategy for cancer therapy. Therefore, the present work portrays the synthesis of a phototoxic anticancer agent by incorporating ruthenium(II) and iridium(III) metals into a biologically active 2,2′-biquinoline moiety, BQ. The complexes, RuBQ and IrBQ, have been revealed as effective anticancer agents with

  药物的光毒性性质在光激活化疗 (PACT) 中对于疾病的选择性治疗具有极其重要的意义。从理性上讲，为了消除活体中癌症的严重性，光毒性分子的设计在建立癌症治疗选择性策略的研究中越来越引起人们的兴趣。因此，本工作描述了通过将钌( II )和铱( III )金属掺入生物活性2,2'-联喹啉部分BQ来合成光毒性抗癌剂。RuBQ和IrBQ复合物已被证明是有效的抗癌剂，与黑暗相比，由于产生大量单线态氧 ( 1 O 2）在可见光（400–700 nm）照射下。与可见光下的RuBQ复合物相比，复合物IrBQ表现出最佳的毒性（MCF-7 中的 IC 50 = 8.75 μM，HeLa 中的 IC 50 = 7.23 μM）。RuBQ和IrBQ显示出相当大的量子产率 ( Φ f ) 以及良好的亲脂性，表明两种复合物在癌细胞中显着积累后具有细胞成像能力。此外，该复合物显示出与生物分子的显着结合倾向，即。脱氧核糖核酸