RuCl₂(AsPh₃)₂[2-(2-nitrobenzylidene)-N-methylhydrazinecarbothioamide] | 1443105-66-5

• 英文名称: RuCl₂(AsPh₃)₂[2-(2-nitrobenzylidene)-N-methylhydrazinecarbothioamide]
• CAS: 1443105-66-5
• 化学式: C₄₅H₃₉As₂Cl₂N₄O₂RuS
• 分子量: 1021.72
• InChiKey: XEUUXCIYNKPTNX-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  trichlorotris(triphenylarsine)ruthenium(III) 、 (E)-2-(2-nitrobenzylidene)-N-methylhydrazinecarbothioamide 在 三乙胺 作用下， 以 甲醇 、 苯 为溶剂， 反应 8.0h， 以54%的产率得到RuCl₂(AsPh₃)₂[2-(2-nitrobenzylidene)-N-methylhydrazinecarbothioamide]
  参考文献：
  名称：

  Mixed ligand ruthenium(III) complexes of benzaldehyde 4-methyl-3-thiosemicarbazones with triphenylphosphine/triphenylarsine co-ligands: Synthesis, DNA binding, DNA cleavage, antioxidative and cytotoxic activity

  摘要：

  The new ruthenium(III) complexes with 4-methyl-3-thiosemicarbazone ligands, (E)-2-(2-chlorobenzylidene)-N-methylhydrazinecarbothioamide (HL1) and (E)-2-(2-nitrobenzylidene)-N-methylhydrazinecarbothioamide (HL2), were prepared and characterized by various physico-chemical and spectroscopic methods. The title compounds act as bidentate, monobasic chelating ligands with S and N as the donor sites and are preferably found in the thiol form in all the complexes studied. The molecular structure of HL1 and HL2 were determined by single crystal X-ray diffraction method. DNA binding of the ligands and complexes were investigated by absorption spectroscopy and IR spectroscopy. It reveals that the compounds bind to nitrogenous bases of DNA via intercalation. The oxidative cleavage of the complexes with CT-DNA inferred that the effects of cleavage are dose dependent. Antioxidant study of the ligands and complexes showed the significant antioxidant activity against DPPH radical. In addition, the in vitro cytotoxicity of the ligands and complexes against MCF-7 cell line was assayed which showed higher cytotoxic activity with the lower IC50 values indicating their efficiency in killing the cancer cells even at low concentrations. (c) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2013.04.051