rac-[Re(CO)3(dppz)(HOOCCH2CH2C5H4N)](1+) | 1329995-42-7

• 英文名称: rac-[Re(CO)3(dppz)(HOOCCH2CH2C5H4N)](1+)
• 英文别名: fac-[Re(CO)3(dipyrido[2,3-a:2',3'-c]phenazine)(3-(pyridin-4-yl)propanoic acid)](1+)
• CAS: 1329995-42-7
• 化学式: C₂₉H₁₉N₅O₅Re
• 分子量: 703.707
• InChiKey: OORRVRGQWQWBOA-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  rac-[Re(CO)3(dppz)(HOOCCH2CH2C5H4N)](1+) 在 [C₆H₄N₃OC(N(CH₃)2)2]PF₆ 、 C₆H₄N₃OH 、 CH₃CH₂N(CH(CH₃)2)2 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 fac-[Re(CO)3(dipyrido[2,3-a:2',3'-c]phenazine)(NC5H4CH2CH2CONH(CH2)7NHC11H12O6N5P-5'-ACAITATACC(GACT)3)](1+)
  参考文献：
  名称：

  Using Metal Complex Reduced States to Monitor the Oxidation of DNA

  摘要：

  Metallointercalating photooxidants interact intimately with the base stack of double-stranded DNA and exhibit rich photophysical and electrochemical properties, making them ideal probes for the study of DNA-mediated charge transport (CT). The complexes [Rh(phi)(2)(bPy')](3+) (phi = 9,10-phenanthrenequinone diimine; bpy' = 4-methyl-4'-(butyric acid)-2,2'-bipyridine), [Ir(ppy),(dppz')](+) (ppy = 2-phenylpyridine; dppz' = 6-(dipyrido [3,2-a:2',3'-c]phenazin-11-yl)hex-5-ynoic acid), and [Re(CO)(3)(dppz)(py')](+) (dppz = dipyrido[2,3-a:2',3'-c]phenazine; py' = 3-(pyridin-4-yl)-propanoic acid) were each covalently tethered to DNA to compare their photooxidation efficiencies. Biochemical studies show that upon irradiation, the three complexes oxidize guanine by long-range DNA-mediated CT with the efficiency: Rh > Re > Ir. Comparison of spectra obtained by spectroelectrochemistry after bulk reduction of the free metal complexes with those obtained by transient absorption (TA) spectroscopy of the conjugates suggests that the reduced metal states form following excitation of the conjugates at 355 nm. Electrochemical experiments and kinetic analysis of the TA decays indicate that the thermodynamic driving force for CT, variations in the efficiency of back electron transfer, and coupling to DNA are the primary factors responsible for the trend observed in the guanine oxidation yields of the three complexes.

  DOI：

  10.1021/ic201511y