| 1453311-06-2

• CAS: 1453311-06-2
• 化学式: C₆₆H₅₂As₂Cl₄FeN₁₀O₄Ru₂S₄
• 分子量: 1727.11
• InChiKey: VEGHLCYYTHKSMI-UHFFFAOYSA-H

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  trichlorotris(triphenylarsine)ruthenium(III) 、 以 四氢呋喃 、 甲醇 、 苯 为溶剂， 反应 10.0h， 以64%的产率得到
  参考文献：
  名称：

  DNA interaction, antioxidant, and in vitro antitumor activity of binuclear ruthenium(III) complexes of benzothiazole-substituted ferrocenyl thiosemicarbazones

  摘要：

  In our search for new anticancer drugs, a series of binuclear ruthenium(III) thiosemicarbazone complexes of the type [RuCl2(EPh3)](2)L (where E = P/As; L = binucleating monobasic tridentate thiosemicarbazone ligand) have been synthesized. Structural features were determined by various physico-chemical and spectral techniques. The interactions of these complexes with CT-DNA were investigated by absorption spectral study, indicates that the binuclear ruthenium(III) complexes form adducts with DNA and has intrinsic binding constant in the range of 1.0 x 10(4)-7.9 x 10(4) M-1. The free radical scavenging activity of binuclear ruthenium(III) complexes have been determined by their interaction with the stable DPPH free radical. All the complexes exhibited significant antiproliferative activity against human breast cancer line, MCF-7. This research may provide knowledge that is an excellent backdrop for the rational design of promising drugs.

  DOI：

  10.1007/s00044-013-0698-x