trans-[PtCl2((rac)-2-methylbutylamine)(triphenylphosphine)] | 1312344-05-0

• 英文名称: trans-[PtCl2((rac)-2-methylbutylamine)(triphenylphosphine)]
• CAS: 1312344-05-0
• 化学式: C₂₃H₂₈Cl₂NPPt
• 分子量: 615.442
• InChiKey: JWSMQSZFLULYMS-HSQVSSIKSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  [Pt(μ-Cl)Cl(triphenylphosphine)]2 、 (S)-(-)-2-甲基丁胺 以 丙酮 为溶剂， 以73%的产率得到trans-[PtCl2((rac)-2-methylbutylamine)(triphenylphosphine)]
  参考文献：
  名称：

  Synthesis, characterization and tumor cell growth inhibition of new trans platinum complexes with phosphane derivatives

  摘要：

  We have reported the synthesis and characterization of two new trans platinum complexes in the phosphane series, where the phosphane ligand is triphenylphosphine [P(Ph)(3)] and the group in the trans configuration is represented by chiral aliphatic amines, (racemic in complex 1 and S-NH2CH2CH(CH3)CH2CH3 in complex 2). The anti-proliferative activity detected in tumor cells treated with the two new complexes is more pronounced when the aliphatic amine is racemic compared to the S-enantiomer. Moreover, for both compounds, the activity is fast after cell exposure and, unlike that of cisplatin, virtually independent of the duration of cell challenge. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.03.034