trans-[PtCl2(NHEt2)(PPh3)] | 119816-71-6

• 英文名称: trans-[PtCl2(NHEt2)(PPh3)]
• 英文别名: trans-[PtCl2(PPh3)(Et2NH)]；trans-[PtCl₂(Et₂NH)(PPh₃)]；PtCl2(PPh3)(NHEt2)
• CAS: 119816-71-6；23311-51-5
• 化学式: C₂₂H₂₆Cl₂NPPt
• 分子量: 601.415
• InChiKey: NTXXLIOWSBCMFD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  cis-PtCl2(PPh3)(1-decene) 、 二乙胺 以 not given 为溶剂， 生成 trans-[PtCl2(NHEt2)(PPh3)]
  参考文献：
  名称：

  Amine Attack on Coordinated Alkenes:  An Interconversion from Anti-Markovnikoff to Markovnikoff Products

  摘要：

  A sequence of alkene complexes of platinum, PtCl2(PPh3)(alkene) (alkene = ethylene, propene, 1-butene, cis-2-butene, 1-hexene, 1-octene, and 1-decene), has been prepared. These complexes are characterized by NMR spectroscopy, including assignment of each proton, and X-ray crystal structures of the 1-propene and 1-hexene complexes. Each complex was reacted with diethylamine. For the 1-hexene, 1-octene, and 1-decene complexes, the amine displaces the alkene. For the smaller alkenes, the diethylamine nucleophilically attacks the coordinated alkene. For propene and 1-butene, the low-temperature addition leads to the anti-Markovnikoff nucleophilic attack, which slowly converts at room temperature to the Markovnikoff product. The transformation from anti-Markovnikoff to Markovnikoff addition occurs without diethylamine dissociation.

  DOI：

  10.1021/ja0469939

文献信息

• Synthesis and reactivity of cis-dichloro(enamine)(amine)platinum(II) complexes
  作者：Sheryl L. Doran、David B. Brown、Christopher W. Allen

  DOI：10.1016/0022-328x(88)80558-8

  日期：1988.2

  The reaction of Zeise's dimer, trans-μ-dichlorobis(ethylene)platinum(II) chloride, with a variety of alkyl-substituted enamines led to complexes of the type cis-[Pt(C(2)-enamine)(amine)Cl2], where the enamine ligand is coordinated to the platinum(II) center through its nucleophilic carbon atom (C(2)) and the amine ligand is derived from the parent enamine. Analogous palladium complexes were prepared

  Zeise的二聚体反式-μ-二氯双（乙烯）铂（II）与各种烷基取代的烯胺的反应导致顺式-[Pt（C（2）-enamine）（amine）Cl 2 ]，其中烯胺配体通过其亲核碳原子（C（2））与铂（II）中心配位，并且胺配体衍生自母体烯胺。制备了类似的钯配合物。通过元素分析，NMR（1 H，13 C）和IR光谱对复合物进行表征。
• Platinum(II) complexes containing unsaturated ligands. Nucleophilic substitution versus nucleophilic attack to ligand: a stereochemistry driven outcome
  作者：Daniela Belli Dell’Amico、Claudio Broglia、Luca Labella、Fabio Marchetti、Daniele Mendola、Simona Samaritani

  DOI：10.1016/j.ica.2012.10.038

  日期：2013.1

  EtCN) towards diethylamine has been investigated. The processes are chemo- (substitution versus addition) and stereo-selective in dependence of the stereochemistry of the precursor. The structures of [SP4-4]-[PtCl(CONEt 2 )(NHEt 2 )(PPh 3 )], [SP4-4]- 1 , trans -[PtCl 2 (NHEt 2 )(PPh 3 )], trans - 2 , and cis -[PtCl 2 (E-)HN C(NEt 2 )Me}(PPh 3 )], cis - 3a , are reported.

  摘要混合配合物[PtCl 2（L）（L'）]（L = MeCN，EtCN，CO），L'= PPh 3的反应活性；L =η2 -C 2 H 4，CO; 已经研究了对二乙胺的L'= MeCN，EtCN）。取决于前体的立体化学，该过程是化学的（取代相对于加成）和立体选择性的。[SP4-4]-[PtCl（CONEt 2）（NHEt 2）（PPh 3）]，[SP4-4] -1，反式-[PtCl 2（NHEt 2）（PPh 3）]，反式-参见图2，并且报道了顺式-[PtCl 2 （E-）HN C（NEt 2）Me}（PPh 3）]，顺式-3a。
• Synthesis, antiproliferative and mitochondrial impairment activities of bis-alkyl-amino transplatinum complexes
  作者：Lisa Dalla Via、Aída N. García-Argáez、Arianna Adami、Silvia Grancara、Pamela Martinis、Antonio Toninello、Daniela Belli Dell’Amico、Luca Labella、Simona Samaritani

  DOI：10.1016/j.bmc.2013.09.025

  日期：2013.11

  A convenient synthetic route and the characterization of complexes trans-[PtCl2(L)(PPh3)] (L = Et2NH (2), (PhCH2)(2)NH (3), (HOCH2CH2)(2)NH) (4) are reported. The antiproliferative activity was evaluated on three human tumor cell lines. The investigation on the mechanism of action highlighted for the most active complex 4 the capacity to affect mitochondrial functions. In particular, both the induction of the mitochondrial permeability transition phenomenon and an aspecific membrane damage occurred, depending on concentration. (C) 2013 Elsevier Ltd. All rights reserved.