2-(2-氟苯氧基)-1-乙胺(HCL) | 263410-37-3

• 中文名称: 2-(2-氟苯氧基)-1-乙胺(HCL)
• 英文名称: 2-(2-Fluorophenoxy)ethylamine, hydrochloride
• 英文别名: 2-(2-Fluorophenoxy)ethanamine hydrochloride；2-(2-fluorophenoxy)ethanamine;hydrochloride
• CAS: 263410-37-3
• 化学式: C₈H₁₀FNO*ClH
• mdl: MFCD06149946
• 分子量: 191.633
• InChiKey: SKZQQAPLSWJXDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.16
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  35.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-chloro-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile 、 2-(2-氟苯氧基)-1-乙胺(HCL) 在 碳酸氢钠 作用下， 以 二甲基亚砜 为溶剂， 反应 27.0h， 生成 2-(2-(2-fluorophenoxy)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)-4-methylnicotinonitrile hydrochloride
  参考文献：
  名称：

  CYANOPYRIDINE DERIVATIVE AND USE THEREOF AS MEDICINE

  摘要：

  公开号：

  EP1876178B1

文献信息

• Cyanopyridine derivative and use thereof as medicine
  申请人：Morioka Masahiko

  公开号：US20090292121A1

  公开（公告）日：2009-11-26

  A therapeutic drug for cancer containing a substance selected from the group consisting of a novel cyanopyridine derivative, a pharmaceutically acceptable salt, a hydrate, a water adduct and a solvate as an active ingredient can be provided.

  可以提供一种治疗癌症的药物，其中包含从新型氰基吡啶衍生物、药学上可接受的盐、水合物、水加合物和溶剂加合物中选择的物质作为活性成分。
• .beta.-Adrenergic blocking agents. 17. 1-Phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propanols
  作者：L. H. Smith、H. Tucker

  DOI：10.1021/jm00222a022

  日期：1977.12

  The synthesis is described of a series of derivatives of 1-phenoxy-3-phenoxyalkylamino-2-propanols and 1-alkoxyalkylamino-3-phenoxy-2-propranols. The compounds were investigated for their beta-adrenoceptor blocking properties and many showed a surprising degree of cardioselectivity when tested in vivo in anesthetized cats for their effects on an isoproterenol-induced tachycardia and depressor response. The structure-activity relationship shown by this series of compounds is related to that of known cardioselective analogues and a possible reason for their cardioselectivity is discussed.
• LACTAMS AS TACHYKININ ANTAGONISTS
  申请人：Pfizer Limited

  公开号：EP1456200A1

  公开（公告）日：2004-09-15
• US7060836B2
  申请人：——

  公开号：US7060836B2

  公开（公告）日：2006-06-13
• US7928126B2
  申请人：——

  公开号：US7928126B2

  公开（公告）日：2011-04-19