| 1018740-96-9

• CAS: 1018740-96-9
• 化学式: C₇₂H₇₂F₆N₂O₆
• 分子量: 1175.36
• InChiKey: CCRXOVFDBUSWLZ-XVXHGXNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.67
• 重原子数：
  86.0
• 可旋转键数：
  4.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  77.54
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  2,8,13,19-Tetrakis(1,1-dimethylethyl)-11H,22H-4,6:6,10:15,17:17,21-tetramethanodibenzo<1,10>dioxacyclooctadecin-23,25-dione 、 (Z)-N-phenyl-1-(4-(trifluoromethyl)phenyl)methanimine oxide 以 甲苯 为溶剂， 反应 72.0h， 以84%的产率得到
  参考文献：
  名称：

  Novel 1,3-dipolar cycloaddition reactions of calix[4]bis(spirodienones): synthesis of isoxazolidine derived macrocycles

  摘要：

  Calix [4]bis(spirodienones) can perform as either 4 pi or 2 pi components in cycloaddition reactions with various carbo- and heterodienophiles and with 1,2-benzoquinones leading to the formation of highly functionalized macrocycles. In this Letter we report, highly regio- and stereoselective 1,3-dipolar cycloaddition reactions of a bis(spirodienone) derivative of calix[4]arene with nitrones that provide easy access to isoxazolidine derived macrocycles in excellent yields. These isoxazolidine derivatives can be considered as direct precursors of 1,3-amino alcohols. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.01.082