[Ru(η6-C6H6)[2,6-dimethylphenyl(pyridin-2-yl)methyleneamine]Cl]PF6 | 882994-91-4

• 英文名称: [Ru(η6-C6H6)[2,6-dimethylphenyl(pyridin-2-yl)methyleneamine]Cl]PF6
• 英文别名: [Ru(η⁶-C₆H₆)[2,6-dimethylphenyl(pyridin-2-yl)methyleneamine]Cl]PF₆；[Ru(η⁶-C₆H₆)[2,6-dimethyl-N-(pyridin-2-ylmethylene)aniline]Cl]PF₆；[(η⁶-bz)Ru(2,6-dimethyl-N-(pyridin-2-ylmethylene)aniline)Cl]PF₆；[Ru(η6-benzene)(NC5H4CHNC6H3-2,6-Me2)Cl]PF6
• CAS: 882994-91-4
• 化学式: C₂₀H₂₀ClN₂Ru*F₆P
• 分子量: 569.879
• InChiKey: XIOQZQOMMWFFBP-QLEKOPPNSA-M

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  (η6-benzene)chloro(2-(2,6-dimethylphenylaminomethyl)pyridine)ruthenium(II) hexafluorophosphate 在 sodium methoxide 、 air 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 [Ru(η6-C6H6)[2,6-dimethylphenyl(pyridin-2-yl)methyleneamine]Cl]PF6
  参考文献：
  名称：

  Diastereospecific and Diastereoselective Syntheses of Ruthenium(II) Complexes Using N,N‘ Bidentate Ligands Aryl-pyridin-2-ylmethyl-amine ArNH-CH₂-2-C₅H₄N and Their Oxidation to Imine Ligands

  摘要：

  Coordination of N,N' bidentate ligands aryl-pyridin-2-ylmethyl-amine ArNH-CH2-2-C5H4N 1 (Ar = 4-CH3-C6H4, 1a; 4-CH3O-C6H4, 1b; 2,6-(CH3)(2)-C6H3, 1c; 4-CF3-C6H4, 1d) to the moieties [Ru(bipy)(2)](2+), [Ru(eta(5)-C5H5)L](+) (L = CH3CN, CO), or [RU(eta(6)-arene)Cl](2+) (arene = benzene, p-cymene) occurs under diastereoselective or diastereospecific conditions. Detailed stereochemical analysis of the new complexes is included. The coordination of these secondary amine ligands activates their oxidation to imines by molecular oxygen in a base-catalyzed reaction and hydrogen peroxide was detected as byproduct. The amine-to-imine oxidation was also observed under the experimental conditions of cyclic voltammetry measurements. Deprotonation of the coordinated amine ligands afforded isolatable amido complexes only for the ligand (1-methyl-1-pyridin-2-yl-ethyl)-p-tolyl-amine, 1e, which doesn't contain hydrogen atoms in a beta position relative to the N-H bond. The structures of [Ru(2,2'-bipyridine)(2)(1b)](PF6)(2), 2b; [Ru(2,2'-bipyridine)(2)(1c)](PF6)(2), 2c; trans-[RuCl2(COD)(1a)], 3; and [RuCl2(eta(6)-C6H6)(1a)]PF6, 4a, have been confirmed by X-ray diffraction studies.

  DOI：

  10.1021/ic051590a

文献信息

• Half-sandwich ruthenium(<scp>ii</scp>) complexes containing N^N-chelated imino-pyridyl ligands that are selectively toxic to cancer cells
  作者：Meng Tian、Juanjuan Li、Shumiao Zhang、Lihua Guo、Xiangdong He、Deliang Kong、Hairong Zhang、Zhe Liu

  DOI：10.1039/c7cc08270c

  日期：——

  Chemotherapy is limited by the poor selectivity towards cancer cells over normal cells. Herein, we designed half-sandwich ruthenium imino-pyridyl complexes [(η6-bz)Ru(N^N)Cl]PF6 to achieve selective cytotoxicity to cancer cells. This kind of ruthenium complexes has unique characteristics and is worthy of further exploration in the design of new anticancer drugs.

  化学疗法由于对癌细胞的选择性比正常细胞差而受到限制。在这里，我们设计了半三明治钌亚氨基吡啶基复合物[（η6-bz）Ru（N ^ N）Cl] PF6，以实现对癌细胞的选择性细胞毒性。这种钌配合物具有独特的特性，值得在新的抗癌药物设计中进行进一步的探索。
• Solvato-polymorph of [(η6-C6H6)RuCl (L)]PF6 (L = (2,6-dimethyl-phenyl-pyridin-2-yl methylene amine)
  作者：Joel M. Gichumbi、Holger B. Friedrich、Bernard Omondi

  DOI：10.1016/j.molstruc.2016.02.040

  日期：2016.6

  A half-sandwich complex salt of ruthenium containing the Schiff base ligand, 2, 6-dimethyl-N-(pyridin-2-ylmethylene)aniline has been synthesized and structurally characterized. The complex salt 1, [(eta(C6H6)-C-6)RuCl(C5H4NCH=N(2,6-(CH3)(2)C6H3)]PF6 was obtained from the reaction of the ruthenium arene precursor, [(eta(6)-C6H6)Ru(mu-Cl)Cl](2) with the Schiff base in a 1:2 ratio followed by treatment with NH4PF6. Its acetone solvate 2, [(eta(6)-C6H6)RuCl(C5H4NCH=N (2, 6- (CH3)(2)C6H3)]PF6, (CH3)(2)CO was obtained by recrystallization of 1 from a solution of hexane and acetone. 1 and 2 crystallize in the monoclinic P2(1)/c and P2(1)/n space groups as blocks and as prisms respectively. The ruthenium centers in 1 and 2 are coordinated to the bidentate Schiff base, to a chloride atom, and to the arene ring to give a pseudo octahedral geometry around them. The whole arrangement is referred to as the familiar three-legged piano stool in which the Schiff base and the Cl atom serve as the base while the arene ring serve as the apex of the stool. Polymorph 2 has an acetone molecule in the asymmetric unit. Of interest is the similar behavior of the solvate on heating which shows the crystals shuttering at about 531.6 and 523.4 K for 1 and 2 respectively. (C) 2016 Elsevier B.V. All rights reserved.