8-(3-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)propyl)tetrahydro-8H-8l5-8,4-(epoxyethano)[1,3,2]oxazasilolo[2,3-b][1,3,2]oxazasilol-4-ium | 934625-79-3

• 英文名称: 8-(3-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)propyl)tetrahydro-8H-8l5-8,4-(epoxyethano)[1,3,2]oxazasilolo[2,3-b][1,3,2]oxazasilol-4-ium
• CAS: 934625-79-3
• 化学式: C₁₅H₂₃FN₄O₆Si
• 分子量: 402.455
• InChiKey: DZYQGYZBTFIAEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  1-(3-aminopropyl)silatrane 、 2,4-二氧代-5-氟-3,4-二氢-1(2H)-嘧啶乙酸 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 8-(3-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)propyl)tetrahydro-8H-8l5-8,4-(epoxyethano)[1,3,2]oxazasilolo[2,3-b][1,3,2]oxazasilol-4-ium
  参考文献：
  名称：

  Synthesis, Antitumor Activity, and SAR of N-Substituted γ-Aminopropylsilatrane Derivatives

  摘要：

  -Aminopropylsilatrane has been reported to possess biological activity against tumor cancer cells with low cytotoxicity in many kinds of silatranes. So some N-substituted -aminopropylsilatrane derivatives were synthesized and assayed by a primary anticancer screening against HT-29, Hela, and MDAMB435 cells by the use of the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method. The structures of these derivatives were confirmed by H-1 NMR, electrospray ionization-mass spectrometry, and elemental analysis. The structure-activity relationship showed that the N-substituted derivatives exhibit better activity in which the -amino group of the silatrane is connected with stronger electron-withdrawing groups.

  DOI：

  10.1080/10426507.2013.829835