| 1442751-14-5

• CAS: 1442751-14-5
• 化学式: C₁₇H₂₁Cl₂N₂O₅PPt
• 分子量: 630.324
• InChiKey: WLJXBUWZVBHYQU-FCQHKQNSSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  cis-dichlorobis(dimethylsulfoxide)platinum(II) 、 diethyl ((benzo[d][1,3]dioxol-5-ylamino)(pyridin-2-yl)methyl)phosphonate 以 乙醇 、 二氯甲烷 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Platinum(II) complexes with mono-aminophosphonate ester targeting group that induce apoptosis through G1 cell-cycle arrest: Synthesis, crystal structure and antitumour activity

  摘要：

  Six new platinum(II) complexes with mono-aminophosphonate ester were synthesized and characterized by elemental analysis, H-1 NMR, ESI-MS as well as single crystal X-ray diffraction analysis. They are mononuclear structures. In all the crystal structures of complexes 1-6, the platinum centre adopts an approximately square-planar geometry, which were found to possess excellent solubility in both organic solvents and water and exhibit considerable cytotoxicity against MG-63, SK-OV-3 and HepG2 cell lines, but low cytotoxicity towards normal human liver cell HL-7702. In contrast to cisplatin, their antitumour activities are achieved through the induction of cell apoptosis by G1 cell-cycle arrest. (c) 2013 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2013.01.055