4-fluoro-N-(2-((4-fluorophenyl)(methyl)amino)-2-oxoethyl)-2-(2-(4-iodophenylamino)-2-oxoethoxy)benzamide | 1462267-14-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-fluoro-N-(2-((4-fluorophenyl)(methyl)amino)-2-oxoethyl)-2-(2-(4-iodophenylamino)-2-oxoethoxy)benzamide
• 英文别名: CID-53230294；4-fluoro-N-[2-(4-fluoro-N-methylanilino)-2-oxoethyl]-2-[2-(4-iodoanilino)-2-oxoethoxy]benzamide
• CAS: 1462267-14-6
• 化学式: C₂₄H₂₀F₂IN₃O₄
• 分子量: 579.342
• InChiKey: UTNAIWUXBNDWFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.7
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] SALICYLIC ACID DERIVATIVES USEFUL AS GLUCOCEREBROSIDASE ACTIVATORS<br/>[FR] DÉRIVÉS D'ACIDE SALICYLIQUE UTILES À TITRE D'ACTIVATEURS DE GLUCOCÉRÉBROSIDASE
  申请人：US HEALTH

  公开号：WO2013148333A1

  公开（公告）日：2013-10-03

  Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R1-R13, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.

  公开了化合物（I）的结构及其药用盐。变量R1-R13，m，n，o和p在此处公开。这些化合物可用于治疗高雪氏病，抑制患有GBA基因突变的患者的高雪氏病症状的发作，并用于治疗帕金森病。还公开了含有化合物（I）的药物组合物和包括给予化合物（I）的治疗方法。
• SALICYLIC ACID DERIVATIVES USEFUL AS GLUCOCEREBROSIDASE ACTIVATORS
  申请人：The USA, as Represented by the Secretary, Department of Health and Human Services

  公开号：US20150065469A1

  公开（公告）日：2015-03-05

  Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R 1 -R 13 , m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.

  公开了公式（I）的化合物及其药学上可接受的盐。变量R1-R13，m，n，o和p在此处公开。这些化合物可用于治疗高氏病，并抑制患有GBA基因突变的患者的高氏病症状的发生，并用于治疗帕金森病。还公开了含有公式（I）化合物的制药组合物和包括给予公式（I）化合物的治疗方法。
• US9464035B2
  申请人：——

  公开号：US9464035B2

  公开（公告）日：2016-10-11