dichloro[2-(phenylselanyl)ethanamine]platinum(II) | 870779-76-3

• 英文名称: dichloro[2-(phenylselanyl)ethanamine]platinum(II)
• CAS: 870779-76-3
• 化学式: C₈H₁₁Cl₂NPtSe
• 分子量: 466.128
• InChiKey: NVZPBLFYQIPZQA-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 苯基-2-氨基乙基硒醚 在 NaOH 、 HCl 作用下， 以 水 为溶剂， 以71%的产率得到dichloro[2-(phenylselanyl)ethanamine]platinum(II)
  参考文献：
  名称：

  Syntheses and structural studies of platinum(II) complexes of O-methylselenomethionine and related ligands

  摘要：

  The complexes dichloro[2-(phenylselanyl)ethanamine]platinum(II), dichloro[2-(benzylselanyl)ethanamine]platinum(II) and dichloro(O-methylselenomethionine)platinum(II) have been prepared and the structure of dichloro(O-methylselenomethionine)piatinum(II) has been determined by single crystal X-ray diffraction. The Pt(II) is in a square planar environment and is coordinated by two cis chloride ligands and a chelating O-methylselenomethionine ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and they are at least threefold less toxic than cisplatin in both cell lines. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2006.03.008