| 419548-93-9

• CAS: 419548-93-9
• 化学式: C₁₀H₁₅Cl₂NO₂PtS₂
• 分子量: 511.353
• InChiKey: GUAHIIQPDQUEFH-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  <2>-Pyridylmercaptoaceton 、 cis-dichlorobis(dimethylsulfoxide)platinum(II) 以 甲醇 为溶剂， 以55.7%的产率得到
  参考文献：
  名称：

  Access to Central Carbon Chirality through Cycloplatination of 1-(2-Pyridinylthio)propanone by cis-[PtCl₂(S-SOMe(p-tolyl))]. The Crystal Structure of (S_sS_c)-[Pt{py{SCHC(O)Me}-2}Cl(SOMe(p-tolyl))]

  摘要：

  Cycloplatination of the prochiral sp(3)C-H bond of 1-(2-pyridinylthio)propanone (py(SCH2C(O)Me)(-2), 1a) by cis-[PtCl2(SOMe2)] in dry ethanol affords [Pt(py(SCHC(O)Me)-2)Cl(SOMe2)] (3a) in 77% isolated yield without any side product. The same reaction using the chiral complex cis-[PtCl2(S-SOMe(p-tolyl))] (the absolute configuration of sulfur is indicated for the coordinated ligand) leads to two cycloplatinated diastereoisomers, 4a (SsRc) and 4b (SsSc), in 12.9 and 33.7% yield, respectively (de 44.6%). Their absolute configuration was deduced from the analysis of the H-1 NMR spectra and confirmed by an X-ray structural investigation of 4b. Diastereomer 4b was shown to react with PPh3 to give the enantiomer [Pt(py(SCHC(O)Me)-2)Cl(PPh3)] with the central carbon chirality only. Rather surprisingly, attempted cycloplatination Of py(SCH2C(O)Ph)-2 (1b) by cis-[PtCl2(SOMe2)] affords the cycloplatinated complex [Pt(pyf(SCHC(O)Ph)-2)Cl(SOMe2)] (3b) in a miserable yield.

  DOI：

  10.1021/om0109399