diaminobis(palmitoyloxy)platinum(VI) chloride | 174201-75-3

• 英文名称: diaminobis(palmitoyloxy)platinum(VI) chloride
• CAS: 174201-75-3
• 化学式: C₃₂H₆₈Cl₂N₂O₄Pt
• 分子量: 810.889
• InChiKey: VGFYAYZSQDYFTR-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  氧代铂 、 棕榈酰氯 在 吡啶 作用下， 以 丙酮 为溶剂， 生成 diaminobis(palmitoyloxy)platinum(VI) chloride
  参考文献：
  名称：

  Galanski, M.; Keppler, B. K., Inorganic Chemistry, 1996, vol. 35, p. 1709 - 1711

  摘要：

  DOI：

文献信息

• Combinatorial-Designed Epidermal Growth Factor Receptor-Targeted Chitosan Nanoparticles for Encapsulation and Delivery of Lipid-Modified Platinum Derivatives in Wild-Type and Resistant Non-Small-Cell Lung Cancer Cells
  作者：Ana Vanessa Nascimento、Amit Singh、Hassan Bousbaa、Domingos Ferreira、Bruno Sarmento、Mansoor M. Amiji

  DOI：10.1021/acs.molpharmaceut.5b00642

  日期：2015.12.7

  Development of efficient and versatile drug delivery platforms to overcome the physical and biological challenges in cancer therapeutics is an area of great interest, and novel materials are actively sought for such applications. Recent strides in polymer science have led to a combinatorial approach for generating a library of materials with different functional identities that can be "mixed and matched" to attain desired characteristics of a delivery vector. We have applied the combinatorial design to chitosan (CS), where the polymer backbone has been modified with polyethylene glycol, epidermal growth factor receptor-binding peptide, and lipid derivatives of varying chain length to encapsulate hydrophobic drugs. Cisplatin, cis-([PtCl2(NH3)(2)]), is one of the most potent chemotherapy drugs broadly administered for cancer treatment. Cisplatin is a hydrophilic drug, and in order for it to be encapsulated in the developed nanosystems, it was modified with lipids of varying chain length. The library of four CS derivatives and six platinum derivatives was self-assembled in aqueous medium and evaluated for physicochemical characteristics and cytotoxic effects in platinum-sensitive and -resistant lung cancer cells. The results show that the lipid-modified platinate encapsulation into CS nanoparticles significantly improved cellular cytotoxicity of the drug. In this work, we have also reinforced the idea that CS is a multifaceted system that can be as successful in delivering small molecules as it has been as a nucleic acids carrier.