dichloro-[ 2-(phenyliminomethyl)quinoline]platinum(II) | 1432584-50-3

• 英文名称: dichloro-[ 2-(phenyliminomethyl)quinoline]platinum(II)
• CAS: 1432584-50-3
• 化学式: C₁₆H₁₂Cl₂N₂Pt
• 分子量: 498.271
• InChiKey: XEXPLPIPWASEMG-DPSBJRLESA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  喹啉-2-甲醛 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 15.0h， 生成 dichloro-[ 2-(phenyliminomethyl)quinoline]platinum(II)
  参考文献：
  名称：

  Imino-quinolyl palladium(II) and platinum(II) complexes: Synthesis, characterization, molecular structures and cytotoxic effect

  摘要：

  Imino-quinolyl ligands L1-L5 were synthesized by condensation reaction sand obtained in good yields. Reactions of the ligands with either PdCl2(cod) or K-2[PtCl4] gave the corresponding palladium(II) and platinum(II) complexes 1-10 also in good yields. All the compounds were characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy. X-ray crystallography was used to confirm the structures of these compounds. Molecular structures of 3 and 5 showed that the ligands coordinate to the metal center through the two nitrogen atoms, generating a distorted square planar geometry around the palladium atom. The new complexes exhibited remarkable cytotoxic activities against MCF-7 and HT-29 cancer cell lines. (C) 2013 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2013.02.029

文献信息

• New platinum(II)-based DNA intercalator: Synthesis, characterization and anticancer activity
  作者：Feng-Yang Wang、Romg Liu、Ke-Bin Huang、Hai-Wen Feng、You-Nian Liu、Hong Liang

  DOI：10.1016/j.inoche.2019.04.039

  日期：2019.7

  Abstract Platinum agents with different action mechanisms from current platinum drugs can be effective candidates overcoming the resistance of platinum-based drugs. Platinum(II)-based DNA intercalators are potent candidate which act through mechanisms distinct from cisplatin. Here, we describe the synthesis and characterize of two platinum (II)-based DNA intercalators containing 2-substituted quinoline

  摘要 与现有铂类药物作用机制不同的铂类药物是克服铂类药物耐药性的有效候选药物。基于铂 (II) 的 DNA 嵌入剂是有效的候选者，其作用机制不同于顺铂。在这里，我们描述了两种含有 2-取代喹啉衍生物作为配体的基于铂 (II) 的 DNA 嵌入剂的合成和表征。与顺铂相比，Qui-Pt-2 总体上表现出更大的体外细胞毒性，并且比顺铂对 SK-OV-3/DDP 的耐药系数更低（1.29 至 3.32）。机理实验表明，Qui-Pt-2 可以通过内在和外在途径诱导 Bel-7404 癌细胞的凋亡，这些途径涉及 ATP 耗竭、线粒体膜电位的丧失。据我们所知，