(1S,2S)-1-(4-fluorophenyl)-3-methylbutene-1,2-diamino-dichloroplatinate (II) | 1421015-07-7

• 英文名称: (1S,2S)-1-(4-fluorophenyl)-3-methylbutene-1,2-diamino-dichloroplatinate (II)
• CAS: 1421015-07-7
• 化学式: C₁₁H₁₅Cl₂FN₂Pt
• 分子量: 461.231
• InChiKey: PPCMJMGDPMJRPI-DKVCYQGWSA-L

反应信息

• 作为产物：
  描述：

  (1S,2S)-15N-1-benzyl-1-(4-fluorophenyl)-3-methylbutane-1,2-diamine hydrochloride 在 10 wt% Pd(OH)2 on carbon 、 氢气 、 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 12.0h， 生成 (1S,2S)-1-(4-fluorophenyl)-3-methylbutene-1,2-diamino-dichloroplatinate (II)
  参考文献：
  名称：

  Synthesis of 15N-labeled vicinal diamines through N-activated chiral aziridines: tools for the NMR study of platinum-based anticancer compounds

  摘要：

  A new method for the synthesis of N-15-labeled chiral beta-diamines from a common precursor, either optically pure amino acids or anti-beta-amino alcohols, is reported. The two diastereomeric series of vicinal diamines are produced through the nucleophilic ring opening of activated chiral aziridines. N-15 was introduced by means of [N-15]-benzylamine, prepared from (NH4Cl)-N-15. The final compounds are highly valuable because [H-1-N-15] NMR is considered a powerful tool for studying the chemical properties of platinum-based complexes. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.079