[Cu(Fc-CH2NHCCH2C6H5OH)(1,10-phenanthroline)](ClO4) | 1429908-48-4

• 英文名称: [Cu(Fc-CH2NHCCH2C6H5OH)(1,10-phenanthroline)](ClO4)
• CAS: 1429908-48-4
• 化学式: C₃₂H₂₈CuFeN₃O₃*ClO₄
• 分子量: 721.436
• InChiKey: PXRBLSGPOGABSZ-NLQDPJAYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  1,10-菲罗啉 、 Ferrocenyl-tyrosine 、 sodium perchlorate 、 copper(II) acetate monohydrate 以 甲醇 、 水 为溶剂， 反应 1.5h， 以74%的产率得到[Cu(Fc-CH2NHCCH2C6H5OH)(1,10-phenanthroline)](ClO4)
  参考文献：
  名称：

  Photocytotoxic ferrocene-appended (l-tyrosine)copper(II) complexes of phenanthroline bases

  摘要：

  Copper(II) complexes of ferrocene(Fc)-conjugated reduced Schiff base of L-tyrosine (Fc-TyrH), viz., [Cu(Fc-Tyr)(L)](ClO4), where L is 1,10-phenanthroline (phen, 1), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 2), dipyrido[3,2-a:2',3'-c]phenazine (dppz, 3) and 2-(naphthalen-1-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (nip, 4), were prepared and tested for their photocytotoxicity in cancer cells. [Cu(Fc-Phe)(phen)](-ClO4) (5) of L-phenylalanine and [Cu(Ph-Tyr)(L)(ClO4)] of the reduced Schiff base Ph-TyrH derived from benzaldehyde and L-tyrosine having phen (6) and dppz (7), and [Cu(Ph-Phe)(phen)(ClO4)] (8) using L-phenylalanine were prepared and used as controls. Complexes 5 and 6 were structurally characterized by X-ray crystallography. A copper(II)-based d-d band near 600 nm and a ferrocenyl band at similar to 450 nm were observed in DMF-Tris-HCI buffer (1:4 v/v) in respective complexes. The complexes are photocleavers of pUC19 DNA in visible light forming (OH)-O-center dot radicals. They are cytotoxic in HeLa (human cervical cancer) and MCF-7 (human breast cancer) cells showing an enhancement of cytotoxicity in visible light. Fluorescence imaging shows nuclear localization of the complexes. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.06.018