[Ru^IICl(1,2-bis(ethylsulfinyl)ethane)(H₂O)]₂(μ-Cl)₂ | 625833-00-3

• 英文名称: [Ru^IICl(1,2-bis(ethylsulfinyl)ethane)(H₂O)]₂(μ-Cl)₂
• 英文别名: [RuCl(1,2-bis(ethylsulfinyl)ethane)(H₂O)]₂(μ-Cl)₂；[RuCl(H2O(meso-1,2-bis(ethylsulfinyl)ethane)]2(μ-Cl)2
• CAS: 625833-00-3
• 化学式: C₁₂H₃₂Cl₄O₆Ru₂S₄
• 分子量: 744.598
• InChiKey: DLOARNCQXLKOGZ-IWQRWCONSA-J

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
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• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Ru^IICl(1,2-bis(ethylsulfinyl)ethane)(H₂O)]₂(μ-Cl)₂ 、 乙酰丙酮 在 NaHCO₃ 作用下， 以 乙醇 为溶剂， 以20%的产率得到[Ru(acetylacetonato)(meso-1,2-bis(ethylsulfinyl)ethane)]*0.5H2O
  参考文献：
  名称：

  Ruthenium(II) acetylacetonato–sulfoxide complexes

  摘要：

  The water-soluble Ru-II acetylacetonato-sulfoxide complexes, cis-Ru(acac)(2)(DMSO)(2) (1) and Ru(acac)(2)(meso-BESE) (2), were synthesized (BESE = 1,2-bis(ethylsulfinyl)ethane = EtS(O)(CH2)(2)S(O)Et). Both complexes were characterized by H-1 and C-13{H-1} NMR, UV-Vis, and IR spectroscopies, as well as MS, elemental analysis, solution conductivity, and cyclic voltammetry, while the molecular structure of 2 was determined also by X-ray crystallography. All sulfoxide ligands are S-bonded. The complexes were tested against human breast cancer cells (MDA-MB-435S) using an in vitro MTT assay, a colorimetric determination of cell viability; IC50 values of >2000 and 1500 +/- 100 muM were determined for 1 and 2, respectively, while cisplatin exhibits an IC50 value of 30 +/- 5 muM. (C) 2003 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s1387-7003(03)00164-3
• 作为产物：
  描述：

  盐酸 、 1,2-bis(ethylsulfinyl)ethane 、 ruthenium(III) chloride trihydrate 以 乙醇 、 水 为溶剂， 反应 10.0h， 以60%的产率得到[Ru^IICl(1,2-bis(ethylsulfinyl)ethane)(H₂O)]₂(μ-Cl)₂
  参考文献：
  名称：

  新型二亚砜及其钌配合物的合成与表征

  摘要：

  摘要报道了通过氧化相应的十种新的二亚砜和四种已知的RS（O）–CH2）n-（O）SR（n = 2或3，R =烷基）形成的合成方法二硫醚，RS（CH2）nSR，使用DMSO或H2O2的酸性溶液作为氧化剂。然后将二氧化硫与市售的RuCl3·H2O，K3（RuCl6）或所谓的Ru'Blue'或'Red'溶液在水溶液或醇（MeOH，EtOH）溶液中反应，从中可以形成各种S键合的亚磺酰基络合物分离出顺式或反式RuIICl2（二亚砜）2型的[RuIICl2（二亚砜）（H2O）] 2（μ-Cl）2和[Ru2II / IIICl（二亚砜）] 2（μ-Cl）3；包括X射线数据在内的所有这三种类型都具有良好的特征。还合成了一种具有桥联二亚砜1,2-双（苯基亚磺酰基）乙烷的RuCl3（BPhSE）] 2（μ-BPhSE）的RuIII配合物，但表征较差。

  DOI：

  10.1016/j.ica.2019.119217

文献信息

• Aqueous chemistry of ruthenium(II) complexes containing dimethylsulfoxide, and a chelated disulfoxide ligand or a cyclotetrathia ligand
  作者：Elizabeth L.S. Cheu、Lynsey A. Huxham、Brian O. Patrick、Maria B. Ezhova、Brian R. James

  DOI：10.1016/j.ica.2020.119866

  日期：2020.11

  The aqueous chemistry, including some kinetic studies, of our recently reported [(RuCl)-Cl-II/III(BPSP)](2)(mu-Cl)(3) (complex 1), where BPSP = 1,2-bis(propylsulfinyl)ethane, and a new complex cis-RuCl2(DMSO)(DMSO)(BESE) (2), where BESE = 1,2-bis(ethylsulfinyl)ethane, is described; both 1 and 2 are fully characterized. Such data are of importance for in vitro studies on cytotoxicity, accumulation and DNA-binding properties in selected cells, findings that will be published elsewhere. Discussed also are the complexes [Ru(12-ane-S4)(DMSO)(H2O)][OTf](2) (3), where 12-ane-S4 = 1,4,7,10-tetrathiacyclododecane, and cis-RuCl2(DMSO)L (4), where L = 3,6,9,14 tetrathiabicyclo-[9.2.1]-tetradeca-11,13-diene. Complexes 3 and 4 were first made by our group, but have been synthesized and studied subsequently by other groups; differences in findings are discussed.