| 1311268-76-4

• CAS: 1311268-76-4
• 化学式: C₄₄H₃₈Cl₄MnN₄O₂
• 分子量: 851.561
• InChiKey: IJPDSWRWQQGKNX-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  水 、 manganese(II) chloride tetrahydrate 、 克霉唑 以 乙醇 、 水 为溶剂， 以75%的产率得到
  参考文献：
  名称：

  Metalloantibiotics: Synthesis and Antimicrobial Activity of Clotrimazole Metal Chelates, Spectroscopic, and Thermal Characterization

  摘要：

  Metal complexes of clotrimazole (CLMZ) drug were prepared and characterized based on elemental analyses, IR, magnetic moment, molar conductance, and thermal analyses techniques. The complexes have the general formulae [MCl2(H2O)2(L)2].yH2O (where M = Mn(II), Cu(II)), Co(II), Ni(II), Zn(II), y = 0 - 3) and [MCl2(H2O)2(L)2]Cl.yH2O (where M = Cr(III) and Fe(III), y=0 - 3). The molar conductance data reveal that bivalent metal chelates are non-electrolytes while Cr(III) and Fe(III) chelates are of 1:1 electrolytes. IR spectra show that CLMZ is coordinated to the metal ions in a neutral unidentate manner with N donor site of the imidazole-N. The geometrical structures of these complexes are octahedral. The thermal behaviour of these chelates was studied and the activation thermodynamic parameters are calculated using Coats-Redfern method. CLMZ and its metal complexes were screened for their antibacterial activity against bacterial and fungi species. The metal complexes are found to have more biological activity than the parent CLMZ drug.

  DOI：

  10.1080/15533174.2011.568440