[Re(CO)3(2-methoxy-isobutyl-isonitrile)3](1+) | 468095-61-6

• 英文名称: [Re(CO)3(2-methoxy-isobutyl-isonitrile)3](1+)
• CAS: 468095-61-6
• 化学式: C₂₁H₃₃N₃O₆Re
• 分子量: 609.717
• InChiKey: UFBZJAPLICTYFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Re(CO)3(2-methoxy-isobutyl-isonitrile)3](1+) 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 [Re(CO)2(2-methoxy-isobutyl-isonitrile)4](1+)
  参考文献：
  名称：

  Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent

  摘要：

  Tc-99m-Sestamibi has been playing an important role in the cardiac imaging for the last decades. Previously, we reported that [Tc-99m(CO)(3)(MIBI)(3)](+) demonstrated a significant location in myocardium with a lower liver uptake as compared with Tc-99m-Sestamibi. In this work, we found that new [Tc-99m(CO)(2)(MIBI)(4)](+) could be prepared with high radiochemical purity. The inter-transformations between [Tc-99m(CO)(3)(H2O)(MIBI)(2)](+), [Tc-99m(CO)(3)(MIBI)(3)](+), and [Tc-99m(CO)(2)(MIBI)(4)](+) were investigated and biodistribution was performed to evaluate the [(99m) Tc(CO)(2)(MIBI)(4)](+) as a myocardial perfusion imaging agent. The results showed that one more CO was replaced by MIBI slowing down the pharmacokinetics. The structure characterization was performed on their corresponding rhenium complexes, and the results indicated that there were differences between Tc-99m-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.02.006
• 作为产物：
  描述：

  [Re(carbonyl)3(water)3]Br 、 四[1-(异氰基)-2-甲氧基-2-甲基丙烷]-铜四氟硼酸盐 在 sodium hydroxide 、 silver nitrate 作用下， 以 水 为溶剂， 生成 [Re(CO)3(2-methoxy-isobutyl-isonitrile)3](1+) 、 [Re(CO)2(2-methoxy-isobutyl-isonitrile)4](1+)
  参考文献：
  名称：

  Preparation and biological evaluation of 99mTc-CO-MIBI as myocardial perfusion imaging agent

  摘要：

  Tc-99m-Sestamibi has been playing an important role in the cardiac imaging for the last decades. Previously, we reported that [Tc-99m(CO)(3)(MIBI)(3)](+) demonstrated a significant location in myocardium with a lower liver uptake as compared with Tc-99m-Sestamibi. In this work, we found that new [Tc-99m(CO)(2)(MIBI)(4)](+) could be prepared with high radiochemical purity. The inter-transformations between [Tc-99m(CO)(3)(H2O)(MIBI)(2)](+), [Tc-99m(CO)(3)(MIBI)(3)](+), and [Tc-99m(CO)(2)(MIBI)(4)](+) were investigated and biodistribution was performed to evaluate the [(99m) Tc(CO)(2)(MIBI)(4)](+) as a myocardial perfusion imaging agent. The results showed that one more CO was replaced by MIBI slowing down the pharmacokinetics. The structure characterization was performed on their corresponding rhenium complexes, and the results indicated that there were differences between Tc-99m-CO-MIBI and Re-CO-MIBI in preparation and hydrophobic characteristics. (C) 2008 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2008.02.006