5-(dimethylamino)-N-[3-[[(Z)-3-propylsulfinylprop-1-enyl]disulfanyl]propyl]naphthalene-1-sulfonamide | 1462911-63-2

• 英文名称: 5-(dimethylamino)-N-[3-[[(Z)-3-propylsulfinylprop-1-enyl]disulfanyl]propyl]naphthalene-1-sulfonamide
• CAS: 1462911-63-2
• 化学式: C₂₁H₃₀N₂O₃S₄
• 分子量: 486.745
• InChiKey: PEJMMMHRRIHRDI-NVNXTCNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  145
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 生成 1-(dansylamino)-4,5,9-trithiadodeca-6-ene-9-oxide 、 5-(dimethylamino)-N-[3-[[(Z)-3-propylsulfinylprop-1-enyl]disulfanyl]propyl]naphthalene-1-sulfonamide
  参考文献：
  名称：

  New Excursions Into the Synthesis and Medicinal Chemistry of the Disulfide Bond

  摘要：

  The presentation discusses two themes of current interest in my research group in conjunction with a garlic mimics program. The first involves a new one-pot methodology for preparing unsymmetrical disulfides in high yield using 1-chlorobenzotriazole (BtCl) as oxidant, which can be applied to a range of functional types. The second part of the lecture will discuss the synthesis of derivatives of the garlic-derived natural product ajoene, in conjunction with an anti-cancer screening program. The synthesis has been used to prepare a fluorescently tagged derivative of the natural product that has been used to investigate localization and mode of action within the cancer cell using confocal laser scanning microscopy.

  DOI：

  10.1080/10426507.2012.736107