K[Pt(II)(digly)Cl] | 171973-99-2

• 英文名称: K[Pt(II)(digly)Cl]
• CAS: 171973-99-2
• 化学式: C₄H₆ClN₂O₃Pt*K
• 分子量: 399.735
• InChiKey: PYIAYTFJFKYGME-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  盐酸 、 K[Pt(II)(digly)Cl] 以 水 为溶剂， 以83%的产率得到
  参考文献：
  名称：

  Platinum(II) Complexes with Diglycine:  X-ray Crystal Structure, ¹⁵N NMR Spectra, and Growth-Inhibitory Activity against Mouse Meth A Solid Tumor in Vivo

  摘要：

  Two new dipeptide complexes of the form H[Pt(digly)Cl] (2) (H(2)digly = glycylglycine) and H[Pt(Hdigly)Cl-2] (4) were newly prepared, and K[Pt(Hdigly)Cl-2] (3) was isolated. Complex 1, K[Pt(digly)Cl], crystallizes in the monoclinic space group C2/c with unit cell dimensions a=25.77(1) Angstrom, b=4.09(2) Angstrom, c=16.432(9) Angstrom, beta=103.74(4)degrees, and Z=8. Complex 3 crystallizes in the monoclinic space group P2(1)/c with unit cell dimensions a=8.892(5) Angstrom, b=11.387(4) Angstrom, c=9.974(4) Angstrom, beta=105.45(4)degrees, Z=4. Complex 4 crystallizes in the monoclinic space group P2(1)/c with unit cell dimensions a=9.311(6) Angstrom, b=7.737(8), c=15.627(4) Angstrom, beta=105.92(3)degrees, Z=4. Complex 4 has the rare iminol type H(2)digly coordinating to Pt. The N-15 chemical shifts and the coupling constants of the deprotonated coordinated amide N were obtained for the first time for these complexes. These amide peaks showed almost no coordination shift compared with the large coordination shift of the amine nitrogen. The coupling constants between Pt and deprotonated nitrogen for K[Pt(Hdigly)Cl-2] were larger than those for K[Pt(dipep)Cl]. The growth inhibition assays of K[Pt(digly)Cl], K[Pt(Hdigly)Cl-2], and cis-diamminedichloroplatinum(II) (cisplatin) against methylcholanthrene-induced Meth A fibrosarcoma (Meth A) solid tumor transplanted in BALB/c mice were measured. In mice, 35.9% of slight growth inhibition was observed in the group administered with K[Pt(digly)Cl] (dose of 26 mg/kg/day), and 40.6% in the group administered with K[Pt(Hdigly)Cl-2] (dose of 52 mg/kg/day), and 45.3% cisplatin (dose of 10 mg/kg/day). The side effects related to the decrease in body weight are milder than that of cisplatin. Their toxicity against normal mouse bone marrow cells was measured. All of them exhibited toxicity against bone marrow cells, but K[Pt(digly)Cl] and K[Pt(Hdigly)Cl-2] had only 1/10 the toxicity of cisplatin.

  DOI：

  10.1021/ic9615180
• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 双甘肽 在 氢氧化钾 作用下， 以 水 为溶剂， 生成 K[Pt(II)(digly)Cl] 、 potassium chloride
  参考文献：
  名称：

  Preparations and¹³C and¹⁹⁵Pt NMR Spectra of Platinum(II) Peptide Complexes and Their Growth-Inhibitory Activity against Mouse Meth A Solid Tumor in Vivo

  摘要：

  合成、纯化并采用多种分析和光谱技术（包括 \({}^{13}\)C、\({}^{195}\)Pt NMR 和 MS(FAB)）对几种二肽配合物 K[Pt(x-gly 或 gly-x)Cl] 进行了表征，其中 x-gly 或 gly-x 代表二肽阴离子（其中 x 为甘氨酸、丙氨酸、缬氨酸或亮氨酸）部分。K[Pt(x-gly)Cl] 型配合物为浅棕色，而 K[Pt(gly-x)Cl] 型配合物在固态或溶液中为淡黄色。前者在水溶液中比后者更不稳定。测定了 K[Pt(alagly)Cl]、K[Pt(glyala)Cl] 和顺铂（cis-diamminedichloroplatinum(II)）对 BALB/c 小鼠皮下移植的甲基胆蒽诱导的 Meth A 纤维肉瘤（Meth A）实体瘤的生长抑制作用。在给予 K[Pt(glyala)Cl] 剂量为 26 mg kg\({}^{-1}\) d\({}^{-1}\)的小鼠组中，观察到 28.9% 的轻微生长抑制。与体重下降相关的副作用较轻微。在目前的给药条件下，顺铂未显示出任何抗肿瘤活性。测定了这些二肽配合物对正常小鼠骨髓细胞的毒性。所有配合物均对骨髓细胞表现出毒性，但 K[Pt(alagly)Cl] 和 K[Pt(glyala)Cl] 的毒性比顺铂低 1000 倍。

  DOI：

  10.1246/bcsj.68.2559