| 1374552-00-7

• CAS: 1374552-00-7
• 化学式: C₂₅H₂₁Cl₂N₂PPt
• 分子量: 646.415
• InChiKey: GRZSIJVAKZSBNA-JCUXNYRXSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  dichloro( 1,5-cyclooctadiene)platinum(ll) 、 C₂₄H₁₉N₂P 以 二氯甲烷 为溶剂， 反应 4.0h， 以76%的产率得到
  参考文献：
  名称：

  Synthesis, characterisation and in vitro evaluation of platinum(II) and gold(I) iminophosphine complexes for anticancer activity

  摘要：

  The reactions of iminophosphine ligands with [PtCl2(COD)], [PtCl2(DMSO)(2)], and [Au(tht)Cl] has been investigated. The new platinum(II) and gold(I) complexes were characterised using elemental analysis, electrospray ionisation-mass spectrometry (ESI-MS), NMR (H-1 and P-31) and IR spectroscopy and X-ray diffraction studies. In vitro cytotoxic study results show that platinum and gold complexes block the proliferation of WHCO1 and KYSE450 cell lines with an IC50 range of 2.16-9.47 mu M. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.09.053

文献信息

• Synthesis and characterization of palladium(II) and platinum(II) metal complexes with iminophosphine ligands: X-ray crystal structures of platinum(II) complexes and use of palladium(II) complexes as pre-catalysts in Heck and Suzuki cross-coupling reactions
  作者：Haleden Chiririwa、Freeman Ntuli、Edison Muzenda、Alfred Muller

  DOI：10.1007/s11243-013-9703-y

  日期：2013.5

  spectrometry (ESI-MS) and elemental analysis. The representative solid-state molecular structures of the platinum complexes 1b and 2b were determined using single crystal X-ray diffraction analysis and revealed that the complexes exhibit a slightly distorted square-planar geometry. Furthermore, the palladium complexes were tested as potential catalysts in the Heck and Suzuki cross-coupling reactions.

  铂配合物 1b 和 2b 的代表性固态分子结构是使用单晶 X 射线衍射分析确定的，并显示配合物表现出轻微扭曲的方形平面几何形状。此外，钯配合物在 Heck 和 Suzuki 交叉偶联反应中作为潜在催化剂进行了测试。