[Au(4,4′-dimethyl-2,2′-bipyridine)Cl2]ClO4 | 917249-09-3

• 英文名称: [Au(4,4′-dimethyl-2,2′-bipyridine)Cl2]ClO4
• 英文别名: [Au(4,4′-dimethyl-2,2′-bipyridine)Cl₂]ClO₄；[Au(4,4′-dmbipy)Cl₂]ClO₄；[Au(III)(4,4'-dimethyl-2,2'-bipyridine)Cl2]ClO4
• CAS: 917249-09-3
• 化学式: C₁₂H₁₂AuCl₂N₂*ClO₄
• 分子量: 551.564
• InChiKey: RCEGBXOVGPVTML-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  4,4'-二甲基-2,2'-联吡啶 、 sodium perchlorate monohydrate 、 四氯金酸水合物 以 乙腈 为溶剂， 反应 0.25h， 以70%的产率得到[Au(4,4′-dimethyl-2,2′-bipyridine)Cl2]ClO4
  参考文献：
  名称：

  Synthesis and characterization of a series of gold(III) complexes with the 4,4′-dimethyl-2,2′-bipyridine ligand: Counterion influence on the cytotoxicity of gold(III) complexes

  摘要：

  A series of Au(III) complexes, [Au(4,4'-dmbipy)X-2]Y-+(-) where X = Cl, Br and Y = [AuCl4], [AuCl2], [ClO4], [AuBr4], were prepared from the reactions of HAuCl4 center dot 3H(2)O/AuBr3 with 4,4'-dimethy1-2,2'-bipyridine (4,4'-dmbipy) in a mixture of alcohol/CH3CN. These complexes were characterized by elemental analysis, IR, UV-Vis, H-1 and C-13 NMR spectroscopy and their structures were studied by the single-crystal diffraction method. The electrochemical behavior of the title complexes were also studied in CH3CN and DMSO using cyclic voltammetry. The cationic parts of the complexes are similar, with a bidentate nitrogenous 4,4'-dmbipy ligand and two halide anions attached to a gold(III) center in a square-planar geometry. However, the effect of the anionic parts of the complexes on the cytotoxic properties was evaluated in four cultures, Vero, A431, HeLa and HT-29 by means of an MTT assay. The results illustrate that the anion part plays an important role in the cytotoxicity of relevant compounds in different cell lines. Complexes 1 and 4, with the similar anion part of [AuX4](-) (X = Cl and Br), displayed good agreement in their anticancer activities toward human cancer cell lines. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2014.04.064

文献信息

• Effect of heterocyclic diimine ligands with donor and acceptor substituents on the spectroscopic and electrochemical properties of Au(III) complexes
  作者：M. A. Ivanov、M. V. Puzyk、T. A. Tkacheva、K. P. Balashev

  DOI：10.1134/s1070363206020010

  日期：2006.2

  The composition, structure, and properties of a series of Au(III) complexes with heterocyclic diimine ligands [Au(N<^>N)Cl-2)](+), where (N<^>N) = 2,2'-bipyridine (Bipy), 4,4'-dimethyl-2,2'-bipyridine (DmBipy), 2,2'-biquinoline (Bqx), 1,10-phenanthroline (Phen), 2,9-dimethyl-1,10-phenanthroline (DmPhen), and 4,7-diphenyl-1,10-phenanthroline (DphPhen), were characterized by H-1 NMR, electronic absorption, and emission spectroscopy and also by cyclic voltammetry. The influence of donor and acceptor substituents on the spectroscopic and electrochemical properties of the Au(III) complexes was revealed.