[Mn(O-niflumato)2(methanol)4] | 1428525-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Mn(O-niflumato)2(methanol)4]
• 英文别名: [Mn(O-niflumato)₂(methanol)₄]
• CAS: 1428525-44-3
• 化学式: C₃₀H₃₂F₆MnN₄O₈
• 分子量: 745.534
• InChiKey: ZTRPPYGHPSTLRM-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  甲醇 、 manganese(II) chloride tetrahydrate 、 氟尼酸 在 potassium hydroxide 作用下， 以 甲醇 为溶剂， 以70%的产率得到[Mn(O-niflumato)2(methanol)4]
  参考文献：
  名称：

  Structure, DNA- and albumin-binding of the manganese(II) complex with the non-steroidal antiinflammatory drug niflumic acid

  摘要：

  The manganese(II) complex with the non-steroidal antiinflammatory drug niflumic acid has been synthesized and characterized. The crystal structure of the complex [Mn(O-niflumato)(2)(methanol)(4)] has been determined by X-ray crystallography, where a monodentate coordination of niflumato ligand was revealed. Niflumic acid and its Mn(II) complex exhibit good binding affinity to human or bovine serum albumin proteins with high binding constant values. UV study of the interaction of the compounds with calf-thymus DNA (CT DNA) has shown that the compounds can bind to CT DNA and [Mn(O-niflumato)(2)(-methanol)(4)] exhibits higher binding constant to CT DNA than free niflumic acid. The compounds can bind to CT DNA via intercalation as concluded by DNA solution viscosity measurements. Competitive studies with ethidium bromide (EB) have shown that the compounds can displace the DNA-bound EB suggesting strong competition with EB. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2013.01.049