trans-[PtCl(NH₃)₂(OH)]•H₂O | 672907-15-2

• 英文名称: trans-[PtCl(NH₃)₂(OH)]•H₂O
• 英文别名: trans-[(amine)2(platinum(II))(OH)Cl]*H2O；trans-[PtCl(hydroxido)(NH3)]*water
• CAS: 672907-15-2
• 化学式: ClH₇N₂OPt*H₂O
• 分子量: 299.617
• InChiKey: ZEHWZPRIMQZCIJ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为反应物：
  描述：

  trans-[PtCl(NH₃)₂(OH)]•H₂O 、 1H-2-pyrazolium nitrate 以 二氯甲烷 、 丙酮 为溶剂， 以54%的产率得到[(trans-PtCl(NH3)2)2(μ-pz(1-))]Cl*3H2O
  参考文献：
  名称：

  Synthetic Route to Dinuclear Platinum(II) Complexes [{trans-PtCl(NH₃)₂}₂(μ-L)]²⁺ (L = Aliphatic or Heterocyclic Diamine) as Potential Antitumor Agents, Exploiting the Mutual Activation of Hydroxido Ligands and Ammonium Groups

  摘要：

  A simple and efficient method for the synthesis of potentially antitumor-active dinuclear platinum complexes of the general formula [(trans-PtCl(NH3)(2)}(2)(mu-L)]((n+2)+) (L = aliphatic or heterocyclic diamine; n = charge of L) is presented. The procedure is based on the mutual in situ activation of trans-[PtCl(OH)(NH3)(2)] and the linker L in the form of a diammoniurn salt. This synthetic pathway yielded the Farrell compound [{trans-PtCl(NH3)(2)}(2){mu-NH2(CH2)(6)NH2)]Cl-2 (BBR3005) in quantitative yield. Using the same procedure, we prepared the new pyrazolate-bridged compound [{trans-PtCl(NH3)(2)(mu-pz)]Cl, determined its X-ray structure, and tested its cytotoxicity against three wild-type and one cisplatin-resistant cell lines.

  DOI：

  10.1021/ic801251k
• 作为产物：
  描述：

  sodium hydroxide 、 transplatin 以 水 为溶剂， 以50%的产率得到trans-[PtCl(NH₃)₂(OH)]•H₂O
  参考文献：
  名称：

  Delton communication. Facile isolation and crystal structure determination of trans-[PtCl(OH)(NH₃)₂]·H₂O

  摘要：

  A substitution-inert OH group has facilitated the isolation of the first hydrolysis product of trans-diamminedichloroplatinum(II); the crystal structure of trans-[PtCl(OH)(NH3)2].H2O has been determined.

  DOI：

  10.1039/dt9940001499

文献信息

• Kinetics and mechanism of complexation of trans-[PtCl(NH3)2(H2O)]+ with inosine and 1-methylinosine in aqueous solution at different pH values
  作者：Marjaana Mikola、Pentti Oksman、Jorma Arpalahti

  DOI：10.1039/dt9960003101

  日期：——

  N7-bound 1 : 1 complex. This binding mode is favoured also with inosine when pH < 6, whereas above this pH N1 becomes an additional binding site which facilitates the formation of a N1,N7-bonded diplatinum species, too. Rate parameters obtained for the formation of the inosine 1 : 1 complexes show that the N7 site is preferred over the N1 site, whereas in the binding of the second platinum(II) unit to the

  通过在298.2 K的水溶液（pH 2.8-8.4）中采用HPLC作为分析方法，研究了反式-[PtCl（NH 3）2（H 2 O）] +与肌苷及其1-甲基衍生物的络合动力学工具。在这些条件下，反式-[PtCl（NH 3）2（H 2 O）] +的行为类似于单官能铂（II）物种。在所研究的整个pH范围内，络合物的形成都可以通过用进入的核苷取代水配体来解释，OH基团似乎对取代呈惰性。1-甲基肌苷仅形成N 7界1：1复合体。当pH <6时，肌苷也有利于这种结合方式，而在此pH之上，N 1成为一个额外的结合位点，这也促进了N 1，N 7键合的双铂物种的形成。用于形成肌苷1：1复合物的速率参数表明，N 7位点优于N 1位点，而在第二个铂（II）单元与不同的1：1复合物结合时，N 1位点比N 7网站更有利。的协调反式- [氯铂酸（NH 3）2（H 2 O）]肌苷N 7位点的+使N 1 H位点的碱性降低约1
• The Challenge of Deciphering Linkage Isomers in Mixtures of Oligomeric Complexes Derived from 9-Methyladenine and<i>trans</i>-(NH₃)₂Pt^IIUnits
  作者：Susana Ibáñez、Béla Mihály、Pablo J. Sanz Miguel、Dirk Steinborn、Irene Pretzer、Wolf Hiller、Bernhard Lippert

  DOI：10.1002/chem.201406378

  日期：2015.4.7

  N9‐substituted adenines, such as the model nucleobase 9‐methyladenine (9MeA), under neutral or weakly acidic pH conditions in water preferably occurs at N1 and/or N7. This leads, not only to mononuclear linkage isomers with N1 or N7 binding, but also to species that involve both N1 and N7 metal binding in the form of dinuclear or oligomeric species. Application of a trans‐(NH3)2PtII unit and restriction of

  在水中的中性或弱酸性pH条件下，金属与N9取代的腺嘌呤（例如模型核碱基9-甲基腺嘌呤（9MeA））的金属配位优选发生在N1和/或N7。这不仅导致具有N1或N7结合的单核键连接异构体，而且还导致涉及以双核或寡聚形式存在的N1和N7金属结合的物质。一个的应用反式- （NH 3）2的Pt II单元和金属配位限制到N1和N7位点和低聚物的大小，以四个金属实体产生超过50个可能的异构体，它们显示不同的可行的连接性。缓慢的相互转换漫游器不包括在此数字中。基于1尝试进行1 H NMR光谱分析，对N1，N7桥联物种的光谱特征进行定性评估。通过研究选择的分离和结构表征的化合物，如溶液行为反式- [氯铂酸（9MeA- N7）（NH 3）2 ] CLO 4 ⋅ 2H 2 O或反式，反式- [氯铂酸（NH 3）2 } 2（9MeA- N1，N7）] [CLO 4 ] 2 ⋅ ħ 2 O，并且还通过一个9MeA复
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 87, page 207 - 209
  作者：

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Pt: MVol.D, 106, page 247 - 248
  作者：

  DOI：——

  日期：——
• 251. Researches on ammines. Part IX. Diaquo-, hydroxoaquo-, and acidohydroxo-diammines of bivalent platinum
  作者：Herbert J. S. King

  DOI：10.1039/jr9380001338

  日期：——