2,2,2-tris[(1,2-dicarba-close-dodecaborane(12)-9-ylthio)methyl]succinate | 1374877-20-9

• 英文名称: 2,2,2-tris[(1,2-dicarba-close-dodecaborane(12)-9-ylthio)methyl]succinate
• CAS: 1374877-20-9
• 化学式: C₁₅H₄₆B₃₀O₄S₃
• 分子量: 711.056
• InChiKey: ORHVZOVFZHOZCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2,2,2-tris[(1,2-dicarba-close-dodecaborane(12)-9-ylthio)methyl]ethanol 、 丁二酰氯 以 1,4-二氧六环 为溶剂， 以82%的产率得到2,2,2-tris[(1,2-dicarba-close-dodecaborane(12)-9-ylthio)methyl]succinate
  参考文献：
  名称：

  From ortho-carbaborane-9-thiol towards new building blocks

  摘要：

  The potential of 1,2-dicarba-closo-dodecaborane(12)-9-thiol, 9-HS-1,2-closo-C2B10H11, for the design of novel building blocks is highlighted by two examples envisioned for incorporation into tumor-selective peptides for boron neutron capture therapy (BNCT). By employing a t-Bu protection strategy the synthesis of a bis-galactosyl-substituted ortho-carbaborane carboxylic acid was elaborated, and the procedure is suggested as a general approach towards carbaboranes with three substituents. Furthermore, a simple route to a tris(ortho-carbaborane) building block starting from pentaerythritol is illustrated. All compounds were synthesized in moderate to high yields and identified by H-1, B-11, and C-13 NMR spectroscopy, IR spectroscopy, mass spectrometry, and in one case by X-ray crystallography. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2012.03.003