2,2-di-n-butyl-6-aza-1,3-dioxa-5-ethyl-2-stannabenzocyclononene | 862538-56-5

• 英文名称: 2,2-di-n-butyl-6-aza-1,3-dioxa-5-ethyl-2-stannabenzocyclononene
• CAS: 862538-56-5
• 化学式: C₃₈H₆₂N₂O₄Sn₂
• 分子量: 848.341
• InChiKey: SGXBCIFMQCCDHQ-PJRFZDRQSA-L

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  2-氨基-1-丁醇 、 二正丁基氧化锡 、 水杨醛 以 甲苯 、 正丁醇 为溶剂， 以78%的产率得到2,2-di-n-butyl-6-aza-1,3-dioxa-5-ethyl-2-stannabenzocyclononene
  参考文献：
  名称：

  Synthesis, Characterization, Biocide and Toxicological Activities of Di-n-butyl- and Diphenyl-tin^IV-Salicyliden-β-Amino Alcohol Derivatives

  摘要：

  The one pot reaction of salicylaldehyde 1, beta-amino alcohols 2a-2c, and di-n-butyltin(IV) oxide 3a or diphenyltin(IV) oxide 3b produced five diorganotin(IV) compounds, 4a-4c, 5a, and 5c, in good yields. All compounds were characterized by IR, H-1, C-13, and Sn-119 NMR spectroscopy, and elemental analysis; furthermore, compounds 4b, 4c, 5a, and 5c were characterized by X-ray diffraction analysis. After the structural characterization, all of the compounds were tested in vitro against Bacillus subtilis (Gram-positive, strain ATCC 6633), Escherichia coli (Gram-negative, strain DH5 alpha), Pseudomonas aeruginosa (Gram-negative, strain BH3), Desulfovibrio longus (strain DSM 6739), and Desulfomicrobium aspheronum (strain DSM 5918) to assess their antimicrobial activity. Compounds 4 and 5 demonstrated a wide range of bactericidal activities against the tested aerobic (one Gram-positive and two Gram-negative subtypes) and anaerobic bacteria (two sulfate-reducing bacteria, SRB). Compound 5 had better bactericidal performances than compound 4. For all of the compounds, the acute toxicity was measured using luminescent bacteria toxicity (LBT-Microtox) tests to track their further environmental impact. According to these results and in order to fulfill environmental regulations, the toxicity of the compounds studied herein can be modulated through the proper selection of the disubstituted tin(IV) moiety.

  DOI：

  10.1021/ic048628o